Rabbit Models for Studying Human Infectious Diseases

Xuwen Peng, John A. Knouse, Krista M. Hernon

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Using an appropriate animal model is crucial for mimicking human disease conditions, and various facets including genetics, anatomy, and pathophysiology should be considered before selecting a model. Rabbits (Oryctolagus cuniculus) are well known for their wide use in production of antibodies, eye research, atherosclerosis and other cardiovascular diseases. However, a systematic description of the rabbit as primary experimental models for the study of various human infectious diseases is unavailable. This review focuses on the human infectious diseases for which rabbits are considered a classic or highly appropriate model, including AIDS (caused by HIV1), adult T-cell leukemia-lymphoma (human T-lymphotropic virus type 1), papilloma or carcinoma (human papillomavirus) , herpetic stromal keratitis (herpes simplex virus type 1), tuberculosis (Mycobacterium tuberculosis), and syphilis (Treponema pallidum). In addition, particular aspects of the husbandry and care of rabbits used in studies of human infectious diseases are described.

Original languageEnglish (US)
Pages (from-to)499-507
Number of pages9
JournalComparative Medicine
Volume65
Issue number6
StatePublished - Dec 1 2015

Fingerprint

infectious diseases
Communicable Diseases
rabbits
Rabbits
Viruses
Treponema pallidum
Herpetic Keratitis
Human herpesvirus 1
keratitis
Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
papilloma
T-cells
Oryctolagus cuniculus
Papillomaviridae
Papilloma
Human Herpesvirus 1
Mycobacterium tuberculosis
antibody formation
Syphilis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Peng, X., Knouse, J. A., & Hernon, K. M. (2015). Rabbit Models for Studying Human Infectious Diseases. Comparative Medicine, 65(6), 499-507.
Peng, Xuwen ; Knouse, John A. ; Hernon, Krista M. / Rabbit Models for Studying Human Infectious Diseases. In: Comparative Medicine. 2015 ; Vol. 65, No. 6. pp. 499-507.
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Peng, X, Knouse, JA & Hernon, KM 2015, 'Rabbit Models for Studying Human Infectious Diseases', Comparative Medicine, vol. 65, no. 6, pp. 499-507.

Rabbit Models for Studying Human Infectious Diseases. / Peng, Xuwen; Knouse, John A.; Hernon, Krista M.

In: Comparative Medicine, Vol. 65, No. 6, 01.12.2015, p. 499-507.

Research output: Contribution to journalReview article

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Peng X, Knouse JA, Hernon KM. Rabbit Models for Studying Human Infectious Diseases. Comparative Medicine. 2015 Dec 1;65(6):499-507.