Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype

the, Reproductive Medicine Network, Reproductive Medicine Network

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome among women with polycystic ovarian syndrome is important for prevention strategies. However, data regarding racial/ethnic differences in metabolic phenotype among women with polycystic ovary syndrome are inconsistent. Objective We sought to determine if there are racial/ethnic differences in insulin resistance, metabolic syndrome, and hyperandrogenemia in women with polycystic ovarian syndrome. Study Design We conducted secondary data analysis of a prospective multicenter, double-blind controlled clinical trial, the Pregnancy in Polycystic Ovary Syndrome II study, conducted in 11 academic health centers. Data on 702 women with polycystic ovarian syndrome aged 18-40 years who met modified Rotterdam criteria for the syndrome and wished to conceive were included in the study. Women were grouped into racial/ethnic categories: non-Hispanic whites, non-Hispanic blacks, and Hispanic. The main outcomes were the prevalence of insulin resistance, metabolic syndrome, and hyperandrogenemia in the different racial/ethnic groups. Results Body mass index (35.1 ± 9.8 vs 35.7 ± 7.9 vs 36.4 ± 7.9 kg/m2) and waist circumference (106.5 ± 21.6 vs 104.9 ± 16.4 vs 108.7 ± 7.3 cm) did not differ significantly between non-Hispanic white, non-Hispanic black, and Hispanic women. Hispanic women with polycystic ovarian syndrome had a significantly higher prevalence of hirsutism (93.8% vs 86.8%), abnormal free androgen index (75.8% vs 56.5%), abnormal homeostasis model assessment (52.3% vs 38.4%), and hyperglycemia (14.8% vs 6.5%), as well as lower sex hormone binding globulin compared to non-Hispanic whites. Non-Hispanic black women had a significantly lower prevalence of metabolic syndrome (24.5% vs 42.2%) compared with Hispanic women, and lower serum triglyceride levels compared to both Hispanics and non-Hispanic whites (85.7 ± 37.3 vs 130.2 ± 57.0 vs 120.1 ± 60.5 mg/dL, P <.01), with a markedly lower prevalence of hypertriglyceridemia (5.1% vs 28.3% vs 30.5%, P < .01) compared to the other 2 groups. Conclusion Hispanic women with polycystic ovarian syndrome have the most severe phenotype, both in terms of hyperandrogenism and metabolic criteria. Non-Hispanic black women have an overall milder polycystic ovarian syndrome phenotype than Hispanics and in some respects, than non-Hispanic white women.

Original languageEnglish (US)
Pages (from-to)493.e1-493.e13
JournalAmerican journal of obstetrics and gynecology
Volume216
Issue number5
DOIs
StatePublished - May 2017

Fingerprint

Polycystic Ovary Syndrome
Phenotype
Hispanic Americans
Type 2 Diabetes Mellitus
Insulin Resistance
Cardiovascular Diseases
Hyperandrogenism
Hirsutism
Sex Hormone-Binding Globulin
Hypertriglyceridemia
Controlled Clinical Trials
Waist Circumference
Ethnic Groups
Hyperglycemia
Androgens
Diabetes Mellitus
Triglycerides
Body Mass Index
Homeostasis

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

the ; Reproductive Medicine Network ; Reproductive Medicine Network. / Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. In: American journal of obstetrics and gynecology. 2017 ; Vol. 216, No. 5. pp. 493.e1-493.e13.
@article{ea676241a2a643c6b8d3a8da07b1005b,
title = "Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype",
abstract = "Background Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome among women with polycystic ovarian syndrome is important for prevention strategies. However, data regarding racial/ethnic differences in metabolic phenotype among women with polycystic ovary syndrome are inconsistent. Objective We sought to determine if there are racial/ethnic differences in insulin resistance, metabolic syndrome, and hyperandrogenemia in women with polycystic ovarian syndrome. Study Design We conducted secondary data analysis of a prospective multicenter, double-blind controlled clinical trial, the Pregnancy in Polycystic Ovary Syndrome II study, conducted in 11 academic health centers. Data on 702 women with polycystic ovarian syndrome aged 18-40 years who met modified Rotterdam criteria for the syndrome and wished to conceive were included in the study. Women were grouped into racial/ethnic categories: non-Hispanic whites, non-Hispanic blacks, and Hispanic. The main outcomes were the prevalence of insulin resistance, metabolic syndrome, and hyperandrogenemia in the different racial/ethnic groups. Results Body mass index (35.1 ± 9.8 vs 35.7 ± 7.9 vs 36.4 ± 7.9 kg/m2) and waist circumference (106.5 ± 21.6 vs 104.9 ± 16.4 vs 108.7 ± 7.3 cm) did not differ significantly between non-Hispanic white, non-Hispanic black, and Hispanic women. Hispanic women with polycystic ovarian syndrome had a significantly higher prevalence of hirsutism (93.8{\%} vs 86.8{\%}), abnormal free androgen index (75.8{\%} vs 56.5{\%}), abnormal homeostasis model assessment (52.3{\%} vs 38.4{\%}), and hyperglycemia (14.8{\%} vs 6.5{\%}), as well as lower sex hormone binding globulin compared to non-Hispanic whites. Non-Hispanic black women had a significantly lower prevalence of metabolic syndrome (24.5{\%} vs 42.2{\%}) compared with Hispanic women, and lower serum triglyceride levels compared to both Hispanics and non-Hispanic whites (85.7 ± 37.3 vs 130.2 ± 57.0 vs 120.1 ± 60.5 mg/dL, P <.01), with a markedly lower prevalence of hypertriglyceridemia (5.1{\%} vs 28.3{\%} vs 30.5{\%}, P < .01) compared to the other 2 groups. Conclusion Hispanic women with polycystic ovarian syndrome have the most severe phenotype, both in terms of hyperandrogenism and metabolic criteria. Non-Hispanic black women have an overall milder polycystic ovarian syndrome phenotype than Hispanics and in some respects, than non-Hispanic white women.",
author = "the and {Reproductive Medicine Network} and {Reproductive Medicine Network} and Lawrence Engmann and Susan Jin and Fangbai Sun and Legro, {Richard S.} and Polotsky, {Alex J.} and Hansen, {Karl R.} and Christos Coutifaris and Diamond, {Michael P.} and Esther Eisenberg and Heping Zhang and Nanette Santoro and C. Bartlebaugh and W. Dodson and S. Estes and C. Gnatuk and J. Ober and R. Brzyski and C. Easton and A. Hernandez and M. Leija and D. Pierce and R. Robinson and A. Awonuga and L. Cedo and A. Cline and K. Collins and S. Krawetz and E. Puscheck and M. Singh and M. Yoscovits and K. Barnhart and K. Lecks and L. Martino and R. Marunich and P. Snyder and R. Alvero and A. Comfort and M. Crow and W. Schlaff and P. Casson and A. Hohmann and S. Mallette and G. Christman and D. Ohl and M. Ringbloom and J. Tang and {Wright Bates}, G. and S. Mason and N. DiMaria and R. Usadi",
year = "2017",
month = "5",
doi = "10.1016/j.ajog.2017.01.003",
language = "English (US)",
volume = "216",
pages = "493.e1--493.e13",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

the, Reproductive Medicine Network & Reproductive Medicine Network 2017, 'Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype', American journal of obstetrics and gynecology, vol. 216, no. 5, pp. 493.e1-493.e13. https://doi.org/10.1016/j.ajog.2017.01.003

Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. / the; Reproductive Medicine Network; Reproductive Medicine Network.

In: American journal of obstetrics and gynecology, Vol. 216, No. 5, 05.2017, p. 493.e1-493.e13.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype

AU - the

AU - Reproductive Medicine Network

AU - Reproductive Medicine Network

AU - Engmann, Lawrence

AU - Jin, Susan

AU - Sun, Fangbai

AU - Legro, Richard S.

AU - Polotsky, Alex J.

AU - Hansen, Karl R.

AU - Coutifaris, Christos

AU - Diamond, Michael P.

AU - Eisenberg, Esther

AU - Zhang, Heping

AU - Santoro, Nanette

AU - Bartlebaugh, C.

AU - Dodson, W.

AU - Estes, S.

AU - Gnatuk, C.

AU - Ober, J.

AU - Brzyski, R.

AU - Easton, C.

AU - Hernandez, A.

AU - Leija, M.

AU - Pierce, D.

AU - Robinson, R.

AU - Awonuga, A.

AU - Cedo, L.

AU - Cline, A.

AU - Collins, K.

AU - Krawetz, S.

AU - Puscheck, E.

AU - Singh, M.

AU - Yoscovits, M.

AU - Barnhart, K.

AU - Lecks, K.

AU - Martino, L.

AU - Marunich, R.

AU - Snyder, P.

AU - Alvero, R.

AU - Comfort, A.

AU - Crow, M.

AU - Schlaff, W.

AU - Casson, P.

AU - Hohmann, A.

AU - Mallette, S.

AU - Christman, G.

AU - Ohl, D.

AU - Ringbloom, M.

AU - Tang, J.

AU - Wright Bates, G.

AU - Mason, S.

AU - DiMaria, N.

AU - Usadi, R.

PY - 2017/5

Y1 - 2017/5

N2 - Background Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome among women with polycystic ovarian syndrome is important for prevention strategies. However, data regarding racial/ethnic differences in metabolic phenotype among women with polycystic ovary syndrome are inconsistent. Objective We sought to determine if there are racial/ethnic differences in insulin resistance, metabolic syndrome, and hyperandrogenemia in women with polycystic ovarian syndrome. Study Design We conducted secondary data analysis of a prospective multicenter, double-blind controlled clinical trial, the Pregnancy in Polycystic Ovary Syndrome II study, conducted in 11 academic health centers. Data on 702 women with polycystic ovarian syndrome aged 18-40 years who met modified Rotterdam criteria for the syndrome and wished to conceive were included in the study. Women were grouped into racial/ethnic categories: non-Hispanic whites, non-Hispanic blacks, and Hispanic. The main outcomes were the prevalence of insulin resistance, metabolic syndrome, and hyperandrogenemia in the different racial/ethnic groups. Results Body mass index (35.1 ± 9.8 vs 35.7 ± 7.9 vs 36.4 ± 7.9 kg/m2) and waist circumference (106.5 ± 21.6 vs 104.9 ± 16.4 vs 108.7 ± 7.3 cm) did not differ significantly between non-Hispanic white, non-Hispanic black, and Hispanic women. Hispanic women with polycystic ovarian syndrome had a significantly higher prevalence of hirsutism (93.8% vs 86.8%), abnormal free androgen index (75.8% vs 56.5%), abnormal homeostasis model assessment (52.3% vs 38.4%), and hyperglycemia (14.8% vs 6.5%), as well as lower sex hormone binding globulin compared to non-Hispanic whites. Non-Hispanic black women had a significantly lower prevalence of metabolic syndrome (24.5% vs 42.2%) compared with Hispanic women, and lower serum triglyceride levels compared to both Hispanics and non-Hispanic whites (85.7 ± 37.3 vs 130.2 ± 57.0 vs 120.1 ± 60.5 mg/dL, P <.01), with a markedly lower prevalence of hypertriglyceridemia (5.1% vs 28.3% vs 30.5%, P < .01) compared to the other 2 groups. Conclusion Hispanic women with polycystic ovarian syndrome have the most severe phenotype, both in terms of hyperandrogenism and metabolic criteria. Non-Hispanic black women have an overall milder polycystic ovarian syndrome phenotype than Hispanics and in some respects, than non-Hispanic white women.

AB - Background Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome among women with polycystic ovarian syndrome is important for prevention strategies. However, data regarding racial/ethnic differences in metabolic phenotype among women with polycystic ovary syndrome are inconsistent. Objective We sought to determine if there are racial/ethnic differences in insulin resistance, metabolic syndrome, and hyperandrogenemia in women with polycystic ovarian syndrome. Study Design We conducted secondary data analysis of a prospective multicenter, double-blind controlled clinical trial, the Pregnancy in Polycystic Ovary Syndrome II study, conducted in 11 academic health centers. Data on 702 women with polycystic ovarian syndrome aged 18-40 years who met modified Rotterdam criteria for the syndrome and wished to conceive were included in the study. Women were grouped into racial/ethnic categories: non-Hispanic whites, non-Hispanic blacks, and Hispanic. The main outcomes were the prevalence of insulin resistance, metabolic syndrome, and hyperandrogenemia in the different racial/ethnic groups. Results Body mass index (35.1 ± 9.8 vs 35.7 ± 7.9 vs 36.4 ± 7.9 kg/m2) and waist circumference (106.5 ± 21.6 vs 104.9 ± 16.4 vs 108.7 ± 7.3 cm) did not differ significantly between non-Hispanic white, non-Hispanic black, and Hispanic women. Hispanic women with polycystic ovarian syndrome had a significantly higher prevalence of hirsutism (93.8% vs 86.8%), abnormal free androgen index (75.8% vs 56.5%), abnormal homeostasis model assessment (52.3% vs 38.4%), and hyperglycemia (14.8% vs 6.5%), as well as lower sex hormone binding globulin compared to non-Hispanic whites. Non-Hispanic black women had a significantly lower prevalence of metabolic syndrome (24.5% vs 42.2%) compared with Hispanic women, and lower serum triglyceride levels compared to both Hispanics and non-Hispanic whites (85.7 ± 37.3 vs 130.2 ± 57.0 vs 120.1 ± 60.5 mg/dL, P <.01), with a markedly lower prevalence of hypertriglyceridemia (5.1% vs 28.3% vs 30.5%, P < .01) compared to the other 2 groups. Conclusion Hispanic women with polycystic ovarian syndrome have the most severe phenotype, both in terms of hyperandrogenism and metabolic criteria. Non-Hispanic black women have an overall milder polycystic ovarian syndrome phenotype than Hispanics and in some respects, than non-Hispanic white women.

UR - http://www.scopus.com/inward/record.url?scp=85014758169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014758169&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2017.01.003

DO - 10.1016/j.ajog.2017.01.003

M3 - Article

C2 - 28104402

AN - SCOPUS:85014758169

VL - 216

SP - 493.e1-493.e13

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -