Abstract
Objectives The incidence of neuroendocrine tumors (NETs) has been steadily increasing. Racial differences in the incidence and survival are mostly unknown. This study examines the racial differences and the underlying causes. Methods We conducted a retrospective, population-based study using datasets from Surveillance, Epidemiology, and End Results (SEER) cancer registry and SEER data linked with Medicare claims (SEER-Medicare). We examined the incidence rates and the effects of patient demographics, clinical characteristics, and socioeconomic factors on survival. Results Of the 15,786 and 1731 cases from SEER and SEER-Medicare, 1991 and 163 were blacks, respectively. We found that blacks had higher NET incidence for all stages, with the largest difference noted in the local stage (4.3 vs 2.6 per 100,000 in whites). We found worse survival for distant-stage black patients, although they more often had clinical factors typically associated with better prognosis in NETs. However, they were also found to have significant unfavorable differences in socioeconomic and sociodemographic factors. Conclusions Blacks have higher incidence of NETs and worse survival compared with other races, especially whites. The influences of neighborhood socioeconomic, sociodemographic, and marital status suggest that social determinants, support mechanisms, and access to health care may be contributing factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1373-1379 |
| Number of pages | 7 |
| Journal | Pancreas |
| Volume | 48 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 1 2019 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Hepatology
- Endocrinology
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Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors. / Shen, Chan; Gu, Dian; Zhou, Shouhao; Xu, Ying; Sarshekeh, Amir Mehrvarz; Halperin, Daniel; Shih, Ya Chen T.; Yao, James C.; Dasari, Arvind.
In: Pancreas, Vol. 48, No. 10, 01.11.2019, p. 1373-1379.Research output: Contribution to journal › Article
TY - JOUR
T1 - Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors
AU - Shen, Chan
AU - Gu, Dian
AU - Zhou, Shouhao
AU - Xu, Ying
AU - Sarshekeh, Amir Mehrvarz
AU - Halperin, Daniel
AU - Shih, Ya Chen T.
AU - Yao, James C.
AU - Dasari, Arvind
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objectives The incidence of neuroendocrine tumors (NETs) has been steadily increasing. Racial differences in the incidence and survival are mostly unknown. This study examines the racial differences and the underlying causes. Methods We conducted a retrospective, population-based study using datasets from Surveillance, Epidemiology, and End Results (SEER) cancer registry and SEER data linked with Medicare claims (SEER-Medicare). We examined the incidence rates and the effects of patient demographics, clinical characteristics, and socioeconomic factors on survival. Results Of the 15,786 and 1731 cases from SEER and SEER-Medicare, 1991 and 163 were blacks, respectively. We found that blacks had higher NET incidence for all stages, with the largest difference noted in the local stage (4.3 vs 2.6 per 100,000 in whites). We found worse survival for distant-stage black patients, although they more often had clinical factors typically associated with better prognosis in NETs. However, they were also found to have significant unfavorable differences in socioeconomic and sociodemographic factors. Conclusions Blacks have higher incidence of NETs and worse survival compared with other races, especially whites. The influences of neighborhood socioeconomic, sociodemographic, and marital status suggest that social determinants, support mechanisms, and access to health care may be contributing factors.
AB - Objectives The incidence of neuroendocrine tumors (NETs) has been steadily increasing. Racial differences in the incidence and survival are mostly unknown. This study examines the racial differences and the underlying causes. Methods We conducted a retrospective, population-based study using datasets from Surveillance, Epidemiology, and End Results (SEER) cancer registry and SEER data linked with Medicare claims (SEER-Medicare). We examined the incidence rates and the effects of patient demographics, clinical characteristics, and socioeconomic factors on survival. Results Of the 15,786 and 1731 cases from SEER and SEER-Medicare, 1991 and 163 were blacks, respectively. We found that blacks had higher NET incidence for all stages, with the largest difference noted in the local stage (4.3 vs 2.6 per 100,000 in whites). We found worse survival for distant-stage black patients, although they more often had clinical factors typically associated with better prognosis in NETs. However, they were also found to have significant unfavorable differences in socioeconomic and sociodemographic factors. Conclusions Blacks have higher incidence of NETs and worse survival compared with other races, especially whites. The influences of neighborhood socioeconomic, sociodemographic, and marital status suggest that social determinants, support mechanisms, and access to health care may be contributing factors.
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UR - http://www.scopus.com/inward/citedby.url?scp=85074545024&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000001431
DO - 10.1097/MPA.0000000000001431
M3 - Article
C2 - 31688604
AN - SCOPUS:85074545024
VL - 48
SP - 1373
EP - 1379
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 10
ER -