Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors

Chan Shen, Dian Gu, Shouhao Zhou, Ying Xu, Amir Mehrvarz Sarshekeh, Daniel Halperin, Ya Chen T. Shih, James C. Yao, Arvind Dasari

Research output: Contribution to journalArticle

Abstract

Objectives The incidence of neuroendocrine tumors (NETs) has been steadily increasing. Racial differences in the incidence and survival are mostly unknown. This study examines the racial differences and the underlying causes. Methods We conducted a retrospective, population-based study using datasets from Surveillance, Epidemiology, and End Results (SEER) cancer registry and SEER data linked with Medicare claims (SEER-Medicare). We examined the incidence rates and the effects of patient demographics, clinical characteristics, and socioeconomic factors on survival. Results Of the 15,786 and 1731 cases from SEER and SEER-Medicare, 1991 and 163 were blacks, respectively. We found that blacks had higher NET incidence for all stages, with the largest difference noted in the local stage (4.3 vs 2.6 per 100,000 in whites). We found worse survival for distant-stage black patients, although they more often had clinical factors typically associated with better prognosis in NETs. However, they were also found to have significant unfavorable differences in socioeconomic and sociodemographic factors. Conclusions Blacks have higher incidence of NETs and worse survival compared with other races, especially whites. The influences of neighborhood socioeconomic, sociodemographic, and marital status suggest that social determinants, support mechanisms, and access to health care may be contributing factors.

Original languageEnglish (US)
Pages (from-to)1373-1379
Number of pages7
JournalPancreas
Volume48
Issue number10
DOIs
StatePublished - Nov 1 2019

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Neuroendocrine Tumors
Epidemiology
Medicare
Survival
Incidence
Health Services Accessibility
Marital Status
Social Class
Registries
Demography
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Shen, Chan ; Gu, Dian ; Zhou, Shouhao ; Xu, Ying ; Sarshekeh, Amir Mehrvarz ; Halperin, Daniel ; Shih, Ya Chen T. ; Yao, James C. ; Dasari, Arvind. / Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors. In: Pancreas. 2019 ; Vol. 48, No. 10. pp. 1373-1379.
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Shen, C, Gu, D, Zhou, S, Xu, Y, Sarshekeh, AM, Halperin, D, Shih, YCT, Yao, JC & Dasari, A 2019, 'Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors', Pancreas, vol. 48, no. 10, pp. 1373-1379. https://doi.org/10.1097/MPA.0000000000001431

Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors. / Shen, Chan; Gu, Dian; Zhou, Shouhao; Xu, Ying; Sarshekeh, Amir Mehrvarz; Halperin, Daniel; Shih, Ya Chen T.; Yao, James C.; Dasari, Arvind.

In: Pancreas, Vol. 48, No. 10, 01.11.2019, p. 1373-1379.

Research output: Contribution to journalArticle

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T1 - Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors

AU - Shen, Chan

AU - Gu, Dian

AU - Zhou, Shouhao

AU - Xu, Ying

AU - Sarshekeh, Amir Mehrvarz

AU - Halperin, Daniel

AU - Shih, Ya Chen T.

AU - Yao, James C.

AU - Dasari, Arvind

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Objectives The incidence of neuroendocrine tumors (NETs) has been steadily increasing. Racial differences in the incidence and survival are mostly unknown. This study examines the racial differences and the underlying causes. Methods We conducted a retrospective, population-based study using datasets from Surveillance, Epidemiology, and End Results (SEER) cancer registry and SEER data linked with Medicare claims (SEER-Medicare). We examined the incidence rates and the effects of patient demographics, clinical characteristics, and socioeconomic factors on survival. Results Of the 15,786 and 1731 cases from SEER and SEER-Medicare, 1991 and 163 were blacks, respectively. We found that blacks had higher NET incidence for all stages, with the largest difference noted in the local stage (4.3 vs 2.6 per 100,000 in whites). We found worse survival for distant-stage black patients, although they more often had clinical factors typically associated with better prognosis in NETs. However, they were also found to have significant unfavorable differences in socioeconomic and sociodemographic factors. Conclusions Blacks have higher incidence of NETs and worse survival compared with other races, especially whites. The influences of neighborhood socioeconomic, sociodemographic, and marital status suggest that social determinants, support mechanisms, and access to health care may be contributing factors.

AB - Objectives The incidence of neuroendocrine tumors (NETs) has been steadily increasing. Racial differences in the incidence and survival are mostly unknown. This study examines the racial differences and the underlying causes. Methods We conducted a retrospective, population-based study using datasets from Surveillance, Epidemiology, and End Results (SEER) cancer registry and SEER data linked with Medicare claims (SEER-Medicare). We examined the incidence rates and the effects of patient demographics, clinical characteristics, and socioeconomic factors on survival. Results Of the 15,786 and 1731 cases from SEER and SEER-Medicare, 1991 and 163 were blacks, respectively. We found that blacks had higher NET incidence for all stages, with the largest difference noted in the local stage (4.3 vs 2.6 per 100,000 in whites). We found worse survival for distant-stage black patients, although they more often had clinical factors typically associated with better prognosis in NETs. However, they were also found to have significant unfavorable differences in socioeconomic and sociodemographic factors. Conclusions Blacks have higher incidence of NETs and worse survival compared with other races, especially whites. The influences of neighborhood socioeconomic, sociodemographic, and marital status suggest that social determinants, support mechanisms, and access to health care may be contributing factors.

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