Racial influence on the polycystic ovary syndrome phenotype: A black and white case-control study

Gwinnett Ladson, William Dodson, Stephanie D. Sweet, Anthony E. Archibong, Allen Kunselman, Laurence Demers, Nancy Williams, Ponjola Coney, Richard Legro

Research output: Contribution to journalArticle

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Abstract

Objective: To estimate racial disparities in the polycystic ovary syndrome (PCOS) phenotype between white and black women with PCOS. Design: Case-control study. Setting: Two academic medical centers. Patient(s): A total of 242 women not taking confounding medications in otherwise good health. Intervention(s): Phenotyping during the follicular phase or anovulation after an overnight fast in women. Main outcome measure(s): Biometric, serum hormones, glycemic and metabolic parameters, and body composition by dual-energy x-ray absorptiometry. Result(s): We studied 77 white and 43 black women with PCOS and 35 white and 87 black controls. Black women with PCOS were similar reproductively to white women with PCOS. Black women with PCOS had lower levels of serum transaminases, higher high-density lipoprotein cholesterol levels (mean difference [MD], 18.2 mg/dL; 95% confidence intervals [CI], 14.3, 22.1 mg/dL), lower triglyceride levels (MD, -43.2 mg/dL; 95% CI, -64.5, -21.9), and enhanced insulinogenic index on the oral glucose tolerance test compared with white women with PCOS. Black women with PCOS had higher bone mineral density (MD, 0.1 g/cm2; 95% CI, 0.1, 0.2 g/cm2), lower percent body fat on dual-energy x-ray absorptiometry (MD, -2.8%; 95% CI, -5.1%, -0.5%), and overall a higher quality of life. Although most of these findings disappeared when the differences with racially matched controls were compared, black women with PCOS compared with black controls had lower estradiol levels than white women with PCOS compared with white controls (MD, -12.9 pg/mL; 95% CI, -24.9, -0.8 pg/mL), higher systolic blood pressure (MD, 9.1 mm Hg; 95% CI, 0.8, 17.4 mm Hg), and lower fasting glucose levels (MD, -12.0 mg/dL; 95% CI, -22.3, -1.7 mg/dL). Conclusion(s): Racial disparities in PCOS phenotype are minor and mixed. Future studies should explore if race impacts treatment effects.

Original languageEnglish (US)
JournalFertility and sterility
Volume96
Issue number1
DOIs
StatePublished - Jan 1 2011

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Polycystic Ovary Syndrome
Case-Control Studies
Phenotype
Confidence Intervals
hydroquinone
X-Rays
Anovulation
Follicular Phase
Glucose Tolerance Test
Transaminases
Body Composition
Serum
Bone Density
HDL Cholesterol
Adipose Tissue
Estradiol
Fasting
Triglycerides
Quality of Life
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Ladson, Gwinnett ; Dodson, William ; Sweet, Stephanie D. ; Archibong, Anthony E. ; Kunselman, Allen ; Demers, Laurence ; Williams, Nancy ; Coney, Ponjola ; Legro, Richard. / Racial influence on the polycystic ovary syndrome phenotype : A black and white case-control study. In: Fertility and sterility. 2011 ; Vol. 96, No. 1.
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title = "Racial influence on the polycystic ovary syndrome phenotype: A black and white case-control study",
abstract = "Objective: To estimate racial disparities in the polycystic ovary syndrome (PCOS) phenotype between white and black women with PCOS. Design: Case-control study. Setting: Two academic medical centers. Patient(s): A total of 242 women not taking confounding medications in otherwise good health. Intervention(s): Phenotyping during the follicular phase or anovulation after an overnight fast in women. Main outcome measure(s): Biometric, serum hormones, glycemic and metabolic parameters, and body composition by dual-energy x-ray absorptiometry. Result(s): We studied 77 white and 43 black women with PCOS and 35 white and 87 black controls. Black women with PCOS were similar reproductively to white women with PCOS. Black women with PCOS had lower levels of serum transaminases, higher high-density lipoprotein cholesterol levels (mean difference [MD], 18.2 mg/dL; 95{\%} confidence intervals [CI], 14.3, 22.1 mg/dL), lower triglyceride levels (MD, -43.2 mg/dL; 95{\%} CI, -64.5, -21.9), and enhanced insulinogenic index on the oral glucose tolerance test compared with white women with PCOS. Black women with PCOS had higher bone mineral density (MD, 0.1 g/cm2; 95{\%} CI, 0.1, 0.2 g/cm2), lower percent body fat on dual-energy x-ray absorptiometry (MD, -2.8{\%}; 95{\%} CI, -5.1{\%}, -0.5{\%}), and overall a higher quality of life. Although most of these findings disappeared when the differences with racially matched controls were compared, black women with PCOS compared with black controls had lower estradiol levels than white women with PCOS compared with white controls (MD, -12.9 pg/mL; 95{\%} CI, -24.9, -0.8 pg/mL), higher systolic blood pressure (MD, 9.1 mm Hg; 95{\%} CI, 0.8, 17.4 mm Hg), and lower fasting glucose levels (MD, -12.0 mg/dL; 95{\%} CI, -22.3, -1.7 mg/dL). Conclusion(s): Racial disparities in PCOS phenotype are minor and mixed. Future studies should explore if race impacts treatment effects.",
author = "Gwinnett Ladson and William Dodson and Sweet, {Stephanie D.} and Archibong, {Anthony E.} and Allen Kunselman and Laurence Demers and Nancy Williams and Ponjola Coney and Richard Legro",
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Racial influence on the polycystic ovary syndrome phenotype : A black and white case-control study. / Ladson, Gwinnett; Dodson, William; Sweet, Stephanie D.; Archibong, Anthony E.; Kunselman, Allen; Demers, Laurence; Williams, Nancy; Coney, Ponjola; Legro, Richard.

In: Fertility and sterility, Vol. 96, No. 1, 01.01.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Racial influence on the polycystic ovary syndrome phenotype

T2 - A black and white case-control study

AU - Ladson, Gwinnett

AU - Dodson, William

AU - Sweet, Stephanie D.

AU - Archibong, Anthony E.

AU - Kunselman, Allen

AU - Demers, Laurence

AU - Williams, Nancy

AU - Coney, Ponjola

AU - Legro, Richard

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objective: To estimate racial disparities in the polycystic ovary syndrome (PCOS) phenotype between white and black women with PCOS. Design: Case-control study. Setting: Two academic medical centers. Patient(s): A total of 242 women not taking confounding medications in otherwise good health. Intervention(s): Phenotyping during the follicular phase or anovulation after an overnight fast in women. Main outcome measure(s): Biometric, serum hormones, glycemic and metabolic parameters, and body composition by dual-energy x-ray absorptiometry. Result(s): We studied 77 white and 43 black women with PCOS and 35 white and 87 black controls. Black women with PCOS were similar reproductively to white women with PCOS. Black women with PCOS had lower levels of serum transaminases, higher high-density lipoprotein cholesterol levels (mean difference [MD], 18.2 mg/dL; 95% confidence intervals [CI], 14.3, 22.1 mg/dL), lower triglyceride levels (MD, -43.2 mg/dL; 95% CI, -64.5, -21.9), and enhanced insulinogenic index on the oral glucose tolerance test compared with white women with PCOS. Black women with PCOS had higher bone mineral density (MD, 0.1 g/cm2; 95% CI, 0.1, 0.2 g/cm2), lower percent body fat on dual-energy x-ray absorptiometry (MD, -2.8%; 95% CI, -5.1%, -0.5%), and overall a higher quality of life. Although most of these findings disappeared when the differences with racially matched controls were compared, black women with PCOS compared with black controls had lower estradiol levels than white women with PCOS compared with white controls (MD, -12.9 pg/mL; 95% CI, -24.9, -0.8 pg/mL), higher systolic blood pressure (MD, 9.1 mm Hg; 95% CI, 0.8, 17.4 mm Hg), and lower fasting glucose levels (MD, -12.0 mg/dL; 95% CI, -22.3, -1.7 mg/dL). Conclusion(s): Racial disparities in PCOS phenotype are minor and mixed. Future studies should explore if race impacts treatment effects.

AB - Objective: To estimate racial disparities in the polycystic ovary syndrome (PCOS) phenotype between white and black women with PCOS. Design: Case-control study. Setting: Two academic medical centers. Patient(s): A total of 242 women not taking confounding medications in otherwise good health. Intervention(s): Phenotyping during the follicular phase or anovulation after an overnight fast in women. Main outcome measure(s): Biometric, serum hormones, glycemic and metabolic parameters, and body composition by dual-energy x-ray absorptiometry. Result(s): We studied 77 white and 43 black women with PCOS and 35 white and 87 black controls. Black women with PCOS were similar reproductively to white women with PCOS. Black women with PCOS had lower levels of serum transaminases, higher high-density lipoprotein cholesterol levels (mean difference [MD], 18.2 mg/dL; 95% confidence intervals [CI], 14.3, 22.1 mg/dL), lower triglyceride levels (MD, -43.2 mg/dL; 95% CI, -64.5, -21.9), and enhanced insulinogenic index on the oral glucose tolerance test compared with white women with PCOS. Black women with PCOS had higher bone mineral density (MD, 0.1 g/cm2; 95% CI, 0.1, 0.2 g/cm2), lower percent body fat on dual-energy x-ray absorptiometry (MD, -2.8%; 95% CI, -5.1%, -0.5%), and overall a higher quality of life. Although most of these findings disappeared when the differences with racially matched controls were compared, black women with PCOS compared with black controls had lower estradiol levels than white women with PCOS compared with white controls (MD, -12.9 pg/mL; 95% CI, -24.9, -0.8 pg/mL), higher systolic blood pressure (MD, 9.1 mm Hg; 95% CI, 0.8, 17.4 mm Hg), and lower fasting glucose levels (MD, -12.0 mg/dL; 95% CI, -22.3, -1.7 mg/dL). Conclusion(s): Racial disparities in PCOS phenotype are minor and mixed. Future studies should explore if race impacts treatment effects.

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