Radiation-associated lens changes in the cardiac catheterization laboratory: Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study

Aris Karatasakis, Harilaos S. Brilakis, Barbara A. Danek, Judit Karacsonyi, Jose Roberto Martinez-Parachini, Phuong Khanh J. Nguyen-Trong, Aya J. Alame, Michele K. Roesle, Bavana V. Rangan, Kenneth Rosenfield, Roxana Mehran, Ehtisham Mahmud, Charles Chambers, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To examine the relationship between occupational exposure to ionizing radiation and the prevalence of lens changes in interventional cardiologists (ICs) and catheterization laboratory (“cath-lab”) staff. Background: Exposure to ionizing radiation is associated with the development of lens opacities. ICs and cath-lab staff can receive high doses of ionizing radiation without protection, and may thus be at risk for lens opacity formation. Methods: We conducted a cross-sectional study at an interventional cardiology conference. Study participants completed a questionnaire pertaining to occupational exposure to radiation and potential confounders for the development of cataracts, followed by slit-lamp examination and grading of lens findings. Results: A total of 117 attendees participated in the study, including 99 (85%; 49 ± 11 years-old; 82% male) with occupational exposure to ionizing radiation and 18 (15%; 39 ± 12 years-old; 61% male) unexposed controls. The prevalence of overall cortical and posterior subcapsular lens changes (including subclinical findings) was higher in exposed participants compared with controls (47 vs. 17%, P = 0.015). Occupational exposure and age over 60 were independent predictors of lens changes (odds ratio [95% CI]: 6.07 [1.38–43.45] and 7.72 [1.60–43.34], respectively). The prevalence of frank opacities was low and similar between the two groups (14 vs. 6%, P = 0.461). Most lens findings consisted of subclinical changes in the periphery of the lens without impact on visual acuity. Conclusions: Compared with unexposed controls, ICs and cath-lab staff had a higher prevalence of lens changes that may be attributable to ionizing radiation exposure. While most of these changes were subclinical, they are important due to the potential to progress to clinical symptoms, highlighting the importance of minimizing staff radiation exposure.

Original languageEnglish (US)
Pages (from-to)647-654
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume91
Issue number4
DOIs
StatePublished - Mar 1 2018

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Cardiac Catheterization
Cataract
Lenses
Ionizing Radiation
Radiation
Occupational Exposure
Catheterization
Radiation Protection
Cardiologists
Cardiology
Visual Acuity
Cross-Sectional Studies
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Karatasakis, A., Brilakis, H. S., Danek, B. A., Karacsonyi, J., Martinez-Parachini, J. R., Nguyen-Trong, P. K. J., ... Brilakis, E. S. (2018). Radiation-associated lens changes in the cardiac catheterization laboratory: Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study. Catheterization and Cardiovascular Interventions, 91(4), 647-654. https://doi.org/10.1002/ccd.27173
Karatasakis, Aris ; Brilakis, Harilaos S. ; Danek, Barbara A. ; Karacsonyi, Judit ; Martinez-Parachini, Jose Roberto ; Nguyen-Trong, Phuong Khanh J. ; Alame, Aya J. ; Roesle, Michele K. ; Rangan, Bavana V. ; Rosenfield, Kenneth ; Mehran, Roxana ; Mahmud, Ehtisham ; Chambers, Charles ; Banerjee, Subhash ; Brilakis, Emmanouil S. / Radiation-associated lens changes in the cardiac catheterization laboratory : Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study. In: Catheterization and Cardiovascular Interventions. 2018 ; Vol. 91, No. 4. pp. 647-654.
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title = "Radiation-associated lens changes in the cardiac catheterization laboratory: Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study",
abstract = "Objective: To examine the relationship between occupational exposure to ionizing radiation and the prevalence of lens changes in interventional cardiologists (ICs) and catheterization laboratory (“cath-lab”) staff. Background: Exposure to ionizing radiation is associated with the development of lens opacities. ICs and cath-lab staff can receive high doses of ionizing radiation without protection, and may thus be at risk for lens opacity formation. Methods: We conducted a cross-sectional study at an interventional cardiology conference. Study participants completed a questionnaire pertaining to occupational exposure to radiation and potential confounders for the development of cataracts, followed by slit-lamp examination and grading of lens findings. Results: A total of 117 attendees participated in the study, including 99 (85{\%}; 49 ± 11 years-old; 82{\%} male) with occupational exposure to ionizing radiation and 18 (15{\%}; 39 ± 12 years-old; 61{\%} male) unexposed controls. The prevalence of overall cortical and posterior subcapsular lens changes (including subclinical findings) was higher in exposed participants compared with controls (47 vs. 17{\%}, P = 0.015). Occupational exposure and age over 60 were independent predictors of lens changes (odds ratio [95{\%} CI]: 6.07 [1.38–43.45] and 7.72 [1.60–43.34], respectively). The prevalence of frank opacities was low and similar between the two groups (14 vs. 6{\%}, P = 0.461). Most lens findings consisted of subclinical changes in the periphery of the lens without impact on visual acuity. Conclusions: Compared with unexposed controls, ICs and cath-lab staff had a higher prevalence of lens changes that may be attributable to ionizing radiation exposure. While most of these changes were subclinical, they are important due to the potential to progress to clinical symptoms, highlighting the importance of minimizing staff radiation exposure.",
author = "Aris Karatasakis and Brilakis, {Harilaos S.} and Danek, {Barbara A.} and Judit Karacsonyi and Martinez-Parachini, {Jose Roberto} and Nguyen-Trong, {Phuong Khanh J.} and Alame, {Aya J.} and Roesle, {Michele K.} and Rangan, {Bavana V.} and Kenneth Rosenfield and Roxana Mehran and Ehtisham Mahmud and Charles Chambers and Subhash Banerjee and Brilakis, {Emmanouil S.}",
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Karatasakis, A, Brilakis, HS, Danek, BA, Karacsonyi, J, Martinez-Parachini, JR, Nguyen-Trong, PKJ, Alame, AJ, Roesle, MK, Rangan, BV, Rosenfield, K, Mehran, R, Mahmud, E, Chambers, C, Banerjee, S & Brilakis, ES 2018, 'Radiation-associated lens changes in the cardiac catheterization laboratory: Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study', Catheterization and Cardiovascular Interventions, vol. 91, no. 4, pp. 647-654. https://doi.org/10.1002/ccd.27173

Radiation-associated lens changes in the cardiac catheterization laboratory : Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study. / Karatasakis, Aris; Brilakis, Harilaos S.; Danek, Barbara A.; Karacsonyi, Judit; Martinez-Parachini, Jose Roberto; Nguyen-Trong, Phuong Khanh J.; Alame, Aya J.; Roesle, Michele K.; Rangan, Bavana V.; Rosenfield, Kenneth; Mehran, Roxana; Mahmud, Ehtisham; Chambers, Charles; Banerjee, Subhash; Brilakis, Emmanouil S.

In: Catheterization and Cardiovascular Interventions, Vol. 91, No. 4, 01.03.2018, p. 647-654.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiation-associated lens changes in the cardiac catheterization laboratory

T2 - Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study

AU - Karatasakis, Aris

AU - Brilakis, Harilaos S.

AU - Danek, Barbara A.

AU - Karacsonyi, Judit

AU - Martinez-Parachini, Jose Roberto

AU - Nguyen-Trong, Phuong Khanh J.

AU - Alame, Aya J.

AU - Roesle, Michele K.

AU - Rangan, Bavana V.

AU - Rosenfield, Kenneth

AU - Mehran, Roxana

AU - Mahmud, Ehtisham

AU - Chambers, Charles

AU - Banerjee, Subhash

AU - Brilakis, Emmanouil S.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Objective: To examine the relationship between occupational exposure to ionizing radiation and the prevalence of lens changes in interventional cardiologists (ICs) and catheterization laboratory (“cath-lab”) staff. Background: Exposure to ionizing radiation is associated with the development of lens opacities. ICs and cath-lab staff can receive high doses of ionizing radiation without protection, and may thus be at risk for lens opacity formation. Methods: We conducted a cross-sectional study at an interventional cardiology conference. Study participants completed a questionnaire pertaining to occupational exposure to radiation and potential confounders for the development of cataracts, followed by slit-lamp examination and grading of lens findings. Results: A total of 117 attendees participated in the study, including 99 (85%; 49 ± 11 years-old; 82% male) with occupational exposure to ionizing radiation and 18 (15%; 39 ± 12 years-old; 61% male) unexposed controls. The prevalence of overall cortical and posterior subcapsular lens changes (including subclinical findings) was higher in exposed participants compared with controls (47 vs. 17%, P = 0.015). Occupational exposure and age over 60 were independent predictors of lens changes (odds ratio [95% CI]: 6.07 [1.38–43.45] and 7.72 [1.60–43.34], respectively). The prevalence of frank opacities was low and similar between the two groups (14 vs. 6%, P = 0.461). Most lens findings consisted of subclinical changes in the periphery of the lens without impact on visual acuity. Conclusions: Compared with unexposed controls, ICs and cath-lab staff had a higher prevalence of lens changes that may be attributable to ionizing radiation exposure. While most of these changes were subclinical, they are important due to the potential to progress to clinical symptoms, highlighting the importance of minimizing staff radiation exposure.

AB - Objective: To examine the relationship between occupational exposure to ionizing radiation and the prevalence of lens changes in interventional cardiologists (ICs) and catheterization laboratory (“cath-lab”) staff. Background: Exposure to ionizing radiation is associated with the development of lens opacities. ICs and cath-lab staff can receive high doses of ionizing radiation without protection, and may thus be at risk for lens opacity formation. Methods: We conducted a cross-sectional study at an interventional cardiology conference. Study participants completed a questionnaire pertaining to occupational exposure to radiation and potential confounders for the development of cataracts, followed by slit-lamp examination and grading of lens findings. Results: A total of 117 attendees participated in the study, including 99 (85%; 49 ± 11 years-old; 82% male) with occupational exposure to ionizing radiation and 18 (15%; 39 ± 12 years-old; 61% male) unexposed controls. The prevalence of overall cortical and posterior subcapsular lens changes (including subclinical findings) was higher in exposed participants compared with controls (47 vs. 17%, P = 0.015). Occupational exposure and age over 60 were independent predictors of lens changes (odds ratio [95% CI]: 6.07 [1.38–43.45] and 7.72 [1.60–43.34], respectively). The prevalence of frank opacities was low and similar between the two groups (14 vs. 6%, P = 0.461). Most lens findings consisted of subclinical changes in the periphery of the lens without impact on visual acuity. Conclusions: Compared with unexposed controls, ICs and cath-lab staff had a higher prevalence of lens changes that may be attributable to ionizing radiation exposure. While most of these changes were subclinical, they are important due to the potential to progress to clinical symptoms, highlighting the importance of minimizing staff radiation exposure.

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DO - 10.1002/ccd.27173

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