Radiation response of haematopoietic cell lines of human origin

Shirley Lehnert, Witold Rybka, Samy Suissa, Dan Giambattisto

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Six human haematopoietic cell lines, five of leukaemic origin, including cells with myeloid, lymphoid and undifferentiated phenotype have been studied with respect to radiation response. The intrinsic radiosensitivity of the cells varied widely, the D0s ranging from 0·53 to 1·39 Gy. Five of the cell lines showed some capacity to accumulate sublethal damage; in three of these, enhanced survival was demonstrated in split-dose experiments. One cell line (HL-60) was anomalous in that although little accumulation of sublethal damage was demonstrable, survival was enhanced by fractionation of the dose. Five of the six cell lines studied were of leukaemic origin. The results support the belief that, in contrast to the almost constant radiosensitivity of normal haematopoietic cell progenitors, leukaemic cell progenitors may show a wide range of radiosensitivites.

Original languageEnglish (US)
Pages (from-to)423-431
Number of pages9
JournalInternational Journal of Radiation Biology
Volume49
Issue number3
DOIs
StatePublished - Jan 1 1985

Fingerprint

Radiation
Cell Line
Radiation Tolerance
Dose Fractionation
Survival
Myeloid Cells
Stem Cells
Phenotype

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Lehnert, Shirley ; Rybka, Witold ; Suissa, Samy ; Giambattisto, Dan. / Radiation response of haematopoietic cell lines of human origin. In: International Journal of Radiation Biology. 1985 ; Vol. 49, No. 3. pp. 423-431.
@article{a9e9f61dbe6341e0b1bdb9fa2846c181,
title = "Radiation response of haematopoietic cell lines of human origin",
abstract = "Six human haematopoietic cell lines, five of leukaemic origin, including cells with myeloid, lymphoid and undifferentiated phenotype have been studied with respect to radiation response. The intrinsic radiosensitivity of the cells varied widely, the D0s ranging from 0·53 to 1·39 Gy. Five of the cell lines showed some capacity to accumulate sublethal damage; in three of these, enhanced survival was demonstrated in split-dose experiments. One cell line (HL-60) was anomalous in that although little accumulation of sublethal damage was demonstrable, survival was enhanced by fractionation of the dose. Five of the six cell lines studied were of leukaemic origin. The results support the belief that, in contrast to the almost constant radiosensitivity of normal haematopoietic cell progenitors, leukaemic cell progenitors may show a wide range of radiosensitivites.",
author = "Shirley Lehnert and Witold Rybka and Samy Suissa and Dan Giambattisto",
year = "1985",
month = "1",
day = "1",
doi = "10.1080/09553008514552651",
language = "English (US)",
volume = "49",
pages = "423--431",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
publisher = "Informa Healthcare",
number = "3",

}

Radiation response of haematopoietic cell lines of human origin. / Lehnert, Shirley; Rybka, Witold; Suissa, Samy; Giambattisto, Dan.

In: International Journal of Radiation Biology, Vol. 49, No. 3, 01.01.1985, p. 423-431.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiation response of haematopoietic cell lines of human origin

AU - Lehnert, Shirley

AU - Rybka, Witold

AU - Suissa, Samy

AU - Giambattisto, Dan

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Six human haematopoietic cell lines, five of leukaemic origin, including cells with myeloid, lymphoid and undifferentiated phenotype have been studied with respect to radiation response. The intrinsic radiosensitivity of the cells varied widely, the D0s ranging from 0·53 to 1·39 Gy. Five of the cell lines showed some capacity to accumulate sublethal damage; in three of these, enhanced survival was demonstrated in split-dose experiments. One cell line (HL-60) was anomalous in that although little accumulation of sublethal damage was demonstrable, survival was enhanced by fractionation of the dose. Five of the six cell lines studied were of leukaemic origin. The results support the belief that, in contrast to the almost constant radiosensitivity of normal haematopoietic cell progenitors, leukaemic cell progenitors may show a wide range of radiosensitivites.

AB - Six human haematopoietic cell lines, five of leukaemic origin, including cells with myeloid, lymphoid and undifferentiated phenotype have been studied with respect to radiation response. The intrinsic radiosensitivity of the cells varied widely, the D0s ranging from 0·53 to 1·39 Gy. Five of the cell lines showed some capacity to accumulate sublethal damage; in three of these, enhanced survival was demonstrated in split-dose experiments. One cell line (HL-60) was anomalous in that although little accumulation of sublethal damage was demonstrable, survival was enhanced by fractionation of the dose. Five of the six cell lines studied were of leukaemic origin. The results support the belief that, in contrast to the almost constant radiosensitivity of normal haematopoietic cell progenitors, leukaemic cell progenitors may show a wide range of radiosensitivites.

UR - http://www.scopus.com/inward/record.url?scp=0022638062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022638062&partnerID=8YFLogxK

U2 - 10.1080/09553008514552651

DO - 10.1080/09553008514552651

M3 - Article

VL - 49

SP - 423

EP - 431

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 3

ER -