Radical Mediated Intramolecular [3-Atom + 2-Atom] Addition and the Synthesis of (±)-Rocaglamide: Model Studies

Ken S. Feldman, Christopher J. Burns

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The cyclopenta[b]benzofuran ring system of the antileukemic natural product rocaglamide can be efficiently prepared by intramolecular [3 + 2] radical mediated addition. The stereochemical relationship that emerges between C(2) and C(3a) upon cyclization is identical with that seen in the natural product.

Original languageEnglish (US)
Pages (from-to)4601-4602
Number of pages2
JournalJournal of Organic Chemistry
Volume56
Issue number15
DOIs
StatePublished - Jul 1 1991

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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