Radionuclide imaging of experimental myocarditis

W. C. Reeves, G. L. Jackson, F. W. Flickinger, H. G. Kwee, E. J. Schwiter, J. Werner, L. Whitesell, M. A. Biddle, G. Copenhaver, B. S. Shaikh, Robert Zelis

Research output: Contribution to journalArticle

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Abstract

The ability of 67Ga citrate and 99mTc pyrophosphate cardiac imaging to detect myocarditis was assessed in an experimental rabbit model. Twenty-three rabbits were imaged approximately 72 hours after infusion of i.v. norepinephrine. Diffuse cardiac uptake was found in 13 of 15 rabbits scanned with 67Ga. Tissue distribution studies documented significant myocardial uptake of 67Ga in those with positive scans. Precordial imaging and tissue distribution studies revealed no cardiac uptake in the eight rabbits scanned with 99mTc. Histologic examination of all 23 hearts revealed qualitatively similar, typical lesions of myocarditis. This study suggests that cardiac imaging with 67Ga may be useful in the detection of myocarditis.

Original languageEnglish (US)
Pages (from-to)640-644
Number of pages5
JournalUnknown Journal
Volume63
Issue number3
DOIs
StatePublished - Jan 1 1981

Fingerprint

Myocarditis
Radionuclide Imaging
Rabbits
Tissue Distribution
Technetium Tc 99m Pyrophosphate
Citric Acid
Norepinephrine
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Reeves, W. C., Jackson, G. L., Flickinger, F. W., Kwee, H. G., Schwiter, E. J., Werner, J., ... Zelis, R. (1981). Radionuclide imaging of experimental myocarditis. Unknown Journal, 63(3), 640-644. https://doi.org/10.1161/01.CIR.63.3.640
Reeves, W. C. ; Jackson, G. L. ; Flickinger, F. W. ; Kwee, H. G. ; Schwiter, E. J. ; Werner, J. ; Whitesell, L. ; Biddle, M. A. ; Copenhaver, G. ; Shaikh, B. S. ; Zelis, Robert. / Radionuclide imaging of experimental myocarditis. In: Unknown Journal. 1981 ; Vol. 63, No. 3. pp. 640-644.
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Reeves, WC, Jackson, GL, Flickinger, FW, Kwee, HG, Schwiter, EJ, Werner, J, Whitesell, L, Biddle, MA, Copenhaver, G, Shaikh, BS & Zelis, R 1981, 'Radionuclide imaging of experimental myocarditis', Unknown Journal, vol. 63, no. 3, pp. 640-644. https://doi.org/10.1161/01.CIR.63.3.640

Radionuclide imaging of experimental myocarditis. / Reeves, W. C.; Jackson, G. L.; Flickinger, F. W.; Kwee, H. G.; Schwiter, E. J.; Werner, J.; Whitesell, L.; Biddle, M. A.; Copenhaver, G.; Shaikh, B. S.; Zelis, Robert.

In: Unknown Journal, Vol. 63, No. 3, 01.01.1981, p. 640-644.

Research output: Contribution to journalArticle

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Reeves WC, Jackson GL, Flickinger FW, Kwee HG, Schwiter EJ, Werner J et al. Radionuclide imaging of experimental myocarditis. Unknown Journal. 1981 Jan 1;63(3):640-644. https://doi.org/10.1161/01.CIR.63.3.640