Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles

D. A. Fitzpatrick, N. D. Heindel, Roger Egolf, H. Walton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Misonidazole, a clinically-effective 2-nitroimidazole hypoxic cell radiation sensitizer, and 12 4-nitro-5-sulfonatoimidazoles were tested in cultured human SW1116 colorectal adenocarcinoma cells for radiosensitizing efficiency. Octanol-water partition coefficients and HPLC capacity factors were determined for all agents as measurements of lipophilicity, and an excellent correlation was found between the two measurements. Cytotoxicity, in vitro glutathione reactivity, and one-electron reduction potential were also determined for each compound to evaluate potential utility as macromolecularly transported radiosensitizers. Ten members of the set were found to be 40 to 300 times more radiotoxic than misonidazole, but no correlation was found between their radiosensitizing efficiencies and the chemical and physical parameters.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalRadiation Research
Volume117
Issue number1
DOIs
StatePublished - Jan 1 1989

Fingerprint

Misonidazole
Colorectal Neoplasms
tumors
Radiation-Sensitizing Agents
Octanols
glutathione
Glutathione
partitions
Adenocarcinoma
reactivity
High Pressure Liquid Chromatography
Electrons
Water
radiation
coefficients
cells
water
electrons
In Vitro Techniques
azomycin

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Fitzpatrick, D. A. ; Heindel, N. D. ; Egolf, Roger ; Walton, H. / Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles. In: Radiation Research. 1989 ; Vol. 117, No. 1. pp. 47-58.
@article{49bfde2446cd4b5b8629fab8208f1b2b,
title = "Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles",
abstract = "Misonidazole, a clinically-effective 2-nitroimidazole hypoxic cell radiation sensitizer, and 12 4-nitro-5-sulfonatoimidazoles were tested in cultured human SW1116 colorectal adenocarcinoma cells for radiosensitizing efficiency. Octanol-water partition coefficients and HPLC capacity factors were determined for all agents as measurements of lipophilicity, and an excellent correlation was found between the two measurements. Cytotoxicity, in vitro glutathione reactivity, and one-electron reduction potential were also determined for each compound to evaluate potential utility as macromolecularly transported radiosensitizers. Ten members of the set were found to be 40 to 300 times more radiotoxic than misonidazole, but no correlation was found between their radiosensitizing efficiencies and the chemical and physical parameters.",
author = "Fitzpatrick, {D. A.} and Heindel, {N. D.} and Roger Egolf and H. Walton",
year = "1989",
month = "1",
day = "1",
doi = "10.2307/3577276",
language = "English (US)",
volume = "117",
pages = "47--58",
journal = "Radiation Research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "1",

}

Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles. / Fitzpatrick, D. A.; Heindel, N. D.; Egolf, Roger; Walton, H.

In: Radiation Research, Vol. 117, No. 1, 01.01.1989, p. 47-58.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles

AU - Fitzpatrick, D. A.

AU - Heindel, N. D.

AU - Egolf, Roger

AU - Walton, H.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Misonidazole, a clinically-effective 2-nitroimidazole hypoxic cell radiation sensitizer, and 12 4-nitro-5-sulfonatoimidazoles were tested in cultured human SW1116 colorectal adenocarcinoma cells for radiosensitizing efficiency. Octanol-water partition coefficients and HPLC capacity factors were determined for all agents as measurements of lipophilicity, and an excellent correlation was found between the two measurements. Cytotoxicity, in vitro glutathione reactivity, and one-electron reduction potential were also determined for each compound to evaluate potential utility as macromolecularly transported radiosensitizers. Ten members of the set were found to be 40 to 300 times more radiotoxic than misonidazole, but no correlation was found between their radiosensitizing efficiencies and the chemical and physical parameters.

AB - Misonidazole, a clinically-effective 2-nitroimidazole hypoxic cell radiation sensitizer, and 12 4-nitro-5-sulfonatoimidazoles were tested in cultured human SW1116 colorectal adenocarcinoma cells for radiosensitizing efficiency. Octanol-water partition coefficients and HPLC capacity factors were determined for all agents as measurements of lipophilicity, and an excellent correlation was found between the two measurements. Cytotoxicity, in vitro glutathione reactivity, and one-electron reduction potential were also determined for each compound to evaluate potential utility as macromolecularly transported radiosensitizers. Ten members of the set were found to be 40 to 300 times more radiotoxic than misonidazole, but no correlation was found between their radiosensitizing efficiencies and the chemical and physical parameters.

UR - http://www.scopus.com/inward/record.url?scp=0024510059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024510059&partnerID=8YFLogxK

U2 - 10.2307/3577276

DO - 10.2307/3577276

M3 - Article

C2 - 2913608

AN - SCOPUS:0024510059

VL - 117

SP - 47

EP - 58

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

IS - 1

ER -