Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles

D. A. Fitzpatrick, N. D. Heindel, R. A. Egolf, H. Walton

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Misonidazole, a clinically-effective 2-nitroimidazole hypoxic cell radiation sensitizer, and 12 4-nitro-5-sulfonatoimidazoles were tested in cultured human SW1116 colorectal adenocarcinoma cells for radiosensitizing efficiency. Octanol-water partition coefficients and HPLC capacity factors were determined for all agents as measurements of lipophilicity, and an excellent correlation was found between the two measurements. Cytotoxicity, in vitro glutathione reactivity, and one-electron reduction potential were also determined for each compound to evaluate potential utility as macromolecularly transported radiosensitizers. Ten members of the set were found to be 40 to 300 times more radiotoxic than misonidazole, but no correlation was found between their radiosensitizing efficiencies and the chemical and physical parameters.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalRadiation research
Volume117
Issue number1
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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