Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma

Mao Bin Meng, Nicholas G. Zaorsky, Chao Jiang, Li Jun Tian, Huan Huan Wang, Chun Lei Liu, Juan Wang, Zhen Tao, Yao Sun, Jun Wang, Qing Song Pang, Lu Jun Zhao, Zhi Yong Yuan, Wang Ping

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: This retrospective study evaluates the efficacy and safety of surgery and chemotherapy (S + CT) vs. radiotherapy and CT (RT + CT) in patients with limited stage small cell esophageal cancer (LS-SCEC). Patients and methods: Patients included in analysis (from our hospital and the literature) were treated with S + CT or RT + CT between 1989 and 2012. The primary end point was overall survival (OS); secondary end points included tumor response and toxicity. Kaplan-Meier OS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS. Results: A total of 127 patients were included: 14 from our hospital and 113 from the literature. Fifty-four (43%) and 73 (57%) patients received S + CT or RT + CT, respectively. The median OS of all patients was 21.0 months. OS was longer for those who received RT + CT rather than S + CT (33.0 vs. 17.5 months, p = 0.02), especially those with N1 disease. Uni- and multi-variate analyses showed tumor location (upper 1/3rd of esophagus) and type of treatment (S + CT) were poor prognostic factors of OS. Conclusion: LS-SCEC patients treated with RT + CT had an improved OS compared to those treated with S + RT. Thus, RT + CT should be considered as a primary approach for these patients.

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalRadiotherapy and Oncology
Volume106
Issue number3
DOIs
StatePublished - Mar 1 2013

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Small Cell Carcinoma
Radiotherapy
Drug Therapy
Survival
Esophageal Neoplasms
Kaplan-Meier Estimate
Esophagus
Neoplasms
Retrospective Studies
Regression Analysis
Safety

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Meng, Mao Bin ; Zaorsky, Nicholas G. ; Jiang, Chao ; Tian, Li Jun ; Wang, Huan Huan ; Liu, Chun Lei ; Wang, Juan ; Tao, Zhen ; Sun, Yao ; Wang, Jun ; Pang, Qing Song ; Zhao, Lu Jun ; Yuan, Zhi Yong ; Ping, Wang. / Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma. In: Radiotherapy and Oncology. 2013 ; Vol. 106, No. 3. pp. 317-322.
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title = "Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma",
abstract = "Background: This retrospective study evaluates the efficacy and safety of surgery and chemotherapy (S + CT) vs. radiotherapy and CT (RT + CT) in patients with limited stage small cell esophageal cancer (LS-SCEC). Patients and methods: Patients included in analysis (from our hospital and the literature) were treated with S + CT or RT + CT between 1989 and 2012. The primary end point was overall survival (OS); secondary end points included tumor response and toxicity. Kaplan-Meier OS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS. Results: A total of 127 patients were included: 14 from our hospital and 113 from the literature. Fifty-four (43{\%}) and 73 (57{\%}) patients received S + CT or RT + CT, respectively. The median OS of all patients was 21.0 months. OS was longer for those who received RT + CT rather than S + CT (33.0 vs. 17.5 months, p = 0.02), especially those with N1 disease. Uni- and multi-variate analyses showed tumor location (upper 1/3rd of esophagus) and type of treatment (S + CT) were poor prognostic factors of OS. Conclusion: LS-SCEC patients treated with RT + CT had an improved OS compared to those treated with S + RT. Thus, RT + CT should be considered as a primary approach for these patients.",
author = "Meng, {Mao Bin} and Zaorsky, {Nicholas G.} and Chao Jiang and Tian, {Li Jun} and Wang, {Huan Huan} and Liu, {Chun Lei} and Juan Wang and Zhen Tao and Yao Sun and Jun Wang and Pang, {Qing Song} and Zhao, {Lu Jun} and Yuan, {Zhi Yong} and Wang Ping",
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Meng, MB, Zaorsky, NG, Jiang, C, Tian, LJ, Wang, HH, Liu, CL, Wang, J, Tao, Z, Sun, Y, Wang, J, Pang, QS, Zhao, LJ, Yuan, ZY & Ping, W 2013, 'Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma', Radiotherapy and Oncology, vol. 106, no. 3, pp. 317-322. https://doi.org/10.1016/j.radonc.2013.01.008

Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma. / Meng, Mao Bin; Zaorsky, Nicholas G.; Jiang, Chao; Tian, Li Jun; Wang, Huan Huan; Liu, Chun Lei; Wang, Juan; Tao, Zhen; Sun, Yao; Wang, Jun; Pang, Qing Song; Zhao, Lu Jun; Yuan, Zhi Yong; Ping, Wang.

In: Radiotherapy and Oncology, Vol. 106, No. 3, 01.03.2013, p. 317-322.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Radiotherapy and chemotherapy are associated with improved outcomes over surgery and chemotherapy in the management of limited-stage small cell esophageal carcinoma

AU - Meng, Mao Bin

AU - Zaorsky, Nicholas G.

AU - Jiang, Chao

AU - Tian, Li Jun

AU - Wang, Huan Huan

AU - Liu, Chun Lei

AU - Wang, Juan

AU - Tao, Zhen

AU - Sun, Yao

AU - Wang, Jun

AU - Pang, Qing Song

AU - Zhao, Lu Jun

AU - Yuan, Zhi Yong

AU - Ping, Wang

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Background: This retrospective study evaluates the efficacy and safety of surgery and chemotherapy (S + CT) vs. radiotherapy and CT (RT + CT) in patients with limited stage small cell esophageal cancer (LS-SCEC). Patients and methods: Patients included in analysis (from our hospital and the literature) were treated with S + CT or RT + CT between 1989 and 2012. The primary end point was overall survival (OS); secondary end points included tumor response and toxicity. Kaplan-Meier OS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS. Results: A total of 127 patients were included: 14 from our hospital and 113 from the literature. Fifty-four (43%) and 73 (57%) patients received S + CT or RT + CT, respectively. The median OS of all patients was 21.0 months. OS was longer for those who received RT + CT rather than S + CT (33.0 vs. 17.5 months, p = 0.02), especially those with N1 disease. Uni- and multi-variate analyses showed tumor location (upper 1/3rd of esophagus) and type of treatment (S + CT) were poor prognostic factors of OS. Conclusion: LS-SCEC patients treated with RT + CT had an improved OS compared to those treated with S + RT. Thus, RT + CT should be considered as a primary approach for these patients.

AB - Background: This retrospective study evaluates the efficacy and safety of surgery and chemotherapy (S + CT) vs. radiotherapy and CT (RT + CT) in patients with limited stage small cell esophageal cancer (LS-SCEC). Patients and methods: Patients included in analysis (from our hospital and the literature) were treated with S + CT or RT + CT between 1989 and 2012. The primary end point was overall survival (OS); secondary end points included tumor response and toxicity. Kaplan-Meier OS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS. Results: A total of 127 patients were included: 14 from our hospital and 113 from the literature. Fifty-four (43%) and 73 (57%) patients received S + CT or RT + CT, respectively. The median OS of all patients was 21.0 months. OS was longer for those who received RT + CT rather than S + CT (33.0 vs. 17.5 months, p = 0.02), especially those with N1 disease. Uni- and multi-variate analyses showed tumor location (upper 1/3rd of esophagus) and type of treatment (S + CT) were poor prognostic factors of OS. Conclusion: LS-SCEC patients treated with RT + CT had an improved OS compared to those treated with S + RT. Thus, RT + CT should be considered as a primary approach for these patients.

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