Raman spectroscopy detects cardiac allograft rejection with molecular specificity

Yoon Gi Chung, Qiang Tu, Dianjun Cao, Shuko Harada, Howard J. Eisen, Chang Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Spatially resolved Raman spectroscopy is shown here to be capable of molecular-specific detection without exogenous labeling. This molecular specificity is achieved by detecting the strong and characteristic Raman spectral signature of an indole derivative, serotonin, whose selective existence in rejected heart transplants serves as the biomarker. The study also corroborates the increasingly recognized role of serotonin receptors in various immune responses, including cardiac allograft rejection. Combining both medical and physical sciences, this work demonstrates the potential use of Raman spectroscopy in replacing the invasive endomyocardial biopsy as the standard for post-transplantation rejection surveillance and presents a new paradigm in advancing clinical care through interdisciplinary studies.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalClinical and Translational Science
Volume2
Issue number3
DOIs
StatePublished - Jul 15 2009

Fingerprint

Raman Spectrum Analysis
Allografts
Raman spectroscopy
Interdisciplinary Studies
Natural Science Disciplines
Transplants
Biopsy
Serotonin Receptors
Graft Rejection
Biomarkers
Labeling
Serotonin
Derivatives
indole

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chung, Yoon Gi ; Tu, Qiang ; Cao, Dianjun ; Harada, Shuko ; Eisen, Howard J. ; Chang, Chang. / Raman spectroscopy detects cardiac allograft rejection with molecular specificity. In: Clinical and Translational Science. 2009 ; Vol. 2, No. 3. pp. 206-210.
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Raman spectroscopy detects cardiac allograft rejection with molecular specificity. / Chung, Yoon Gi; Tu, Qiang; Cao, Dianjun; Harada, Shuko; Eisen, Howard J.; Chang, Chang.

In: Clinical and Translational Science, Vol. 2, No. 3, 15.07.2009, p. 206-210.

Research output: Contribution to journalArticle

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