Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.

D. Thiboutot, M. H. Gold, M. T. Jarratt, S. Kang, D. L. Kaplan, L. Millikan, J. Wolfe, C. Loesche, M. Baker

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A prior meta-analysis of 5 randomized controlled trials indicates that adapalene gel 0.1% is as effective as tretinoin gel 0.025% against acne and has greater tolerability. To determine the tolerability and efficacy of adapalene gel 0.1% versus tretinoin microsphere gel 0.1% in 168 patients with acne vulgaris, we conducted a 12-week, multicenter, randomized, controlled, investigator-masked, parallel-group design study. Efficacy variables included noninflammatory, inflammatory, and total lesion counts; global grade; and global assessment of improvement in acne severity. Skin tolerability variables included erythema, desquamation (scaling), dryness, pruritus, and stinging/burning. Our results showed that the efficacy of adapalene gel 0.1% was comparable to that of tretinoin microsphere gel, and both treatments had similar onset of action. Cutaneous tolerability was noted in both groups, with scores significantly better with adapalene gel 0.1% than with tretinoin microsphere gel 0.1%, and significantly fewer treatment-related adverse events were reported with adapalene gel 0.1%.

Original languageEnglish (US)
Pages (from-to)10-19
Number of pages10
JournalCutis; cutaneous medicine for the practitioner
Volume68
Issue number4 Suppl
StatePublished - Oct 2001

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Acne Vulgaris
Tretinoin
Microspheres
Randomized Controlled Trials
Gels
Safety
Therapeutics
Adapalene
Skin
Erythema
Pruritus
Meta-Analysis
Research Personnel

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Thiboutot, D. ; Gold, M. H. ; Jarratt, M. T. ; Kang, S. ; Kaplan, D. L. ; Millikan, L. ; Wolfe, J. ; Loesche, C. ; Baker, M. / Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris. In: Cutis; cutaneous medicine for the practitioner. 2001 ; Vol. 68, No. 4 Suppl. pp. 10-19.
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Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris. / Thiboutot, D.; Gold, M. H.; Jarratt, M. T.; Kang, S.; Kaplan, D. L.; Millikan, L.; Wolfe, J.; Loesche, C.; Baker, M.

In: Cutis; cutaneous medicine for the practitioner, Vol. 68, No. 4 Suppl, 10.2001, p. 10-19.

Research output: Contribution to journalArticle

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AU - Gold, M. H.

AU - Jarratt, M. T.

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AU - Kaplan, D. L.

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AU - Loesche, C.

AU - Baker, M.

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