Randomized Prospective Evaluation of Intraoperative Intravenous Acetaminophen in Pediatric Adenotonsillectomy

Christopher A. Roberts, Shivani Shah-Becker, Ashley O’Connell Ferster, Aaron Baker, Lauren E. Stahl, Khaled Sedeek, Michele M. Carr

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective: To establish the safety and efficacy of single-dose intraoperative intravenous (IV) acetaminophen in postoperative pain management following adenotonsillectomy in addition to a standardized regimen of oral pain medication. Study Design: Randomized, controlled prospective clinical trial. Setting: Single academic medical center. Subjects and Methods: Patients between the ages of 3 and 17 years scheduled for tonsillectomy or adenotonsillectomy by a single surgeon between December 2014 and November 2016 were recruited. Patients were randomly assigned to 1 of 2 groups; group 1 received a single intraoperative dose of IV acetaminophen, and group 2 did not. Induction and maintenance of anesthesia, as well as operative technique, were standardized. Nursing pain scores, pain medications administered, and recovery times were reviewed during the 24-hour postoperative period. Postoperative pain regimen included standing alternating oral acetaminophen and ibuprofen. Results: In total, 260 patients were included in the study, and 131 (50.4%) received a single intraoperative dose of IV acetaminophen. Patients receiving IV acetaminophen were more likely to experience postoperative nausea and vomiting than patients who did not receive IV acetaminophen (1.53% vs 0.00%, P =.016). There were no significant differences noted for postoperative pain scores, requirements for breakthrough pain medications, time to discharge from the recovery room or hospital, or postoperative complications. Conclusion: The use of a single intraoperative dose of IV acetaminophen was associated with minimal additional adverse effects. However, a single intraoperative IV dose of acetaminophen added to standard narcotic and nonnarcotic pain medication does not provide a statistically significant improvement in pain control.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume158
Issue number2
DOIs
StatePublished - Feb 1 2018

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this