Randomized study of probiotics in primary care

Jasmeeta Patel, William J. Curry, Marie A. Graybill, Shaina Bernard, Anna S. Mcdermott, Kelly Karpa

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objectives: Several studies have demonstrated that probiotics can be helpful in preventing antibiotic-associated diarrhoea in hospitalized patients. However, the extent to which probiotics may benefit healthy adults taking a course of antibiotics has not been investigated in primary care. Furthermore, patient willingness to take a probiotic supplement concomitantly with antibiotics has not been explored. We aimed to conduct an exploratory study using probiotics in adults requiring an acute course of antibiotic therapy. Methods: Patients prescribed antibiotics for treatment of acute infections in an outpatient family practice setting were randomized to receive either a probiotic or placebo concurrently. Patients completed adherence diaries and daily symptom checklists to assess gastrointestinal and vaginal (women) symptoms and collect information about adherence. Key findings: During 179.5h in which patients were actively recruited, 952 individuals sought care at the family practice clinic. Of these individuals, 124 were prescribed oral antibiotics; ultimately, 51 individuals met eligibility criteria, consented to participate and were randomized. Forty participants (78.4%) returned symptom diaries. No adverse effects were reported from probiotic use; however, adherence was better with the prescribed antibiotic regimen than with the study supplement (P=0.0033). Conclusion: In our pilot study, probiotics were well tolerated, although no differences were detected in any gastrointestinal or vaginal symptoms between probiotic or placebo.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalJournal of Pharmaceutical Health Services Research
Volume5
Issue number3
DOIs
StatePublished - Sep 2014

All Science Journal Classification (ASJC) codes

  • Economics, Econometrics and Finance (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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