Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report

R. Shapiro, M. L. Jordan, V. P. Scantlebury, J. J. Fung, C. Jensen, C. Vivas, J. McCauley, W. D. Irish, S. Mitchell, A. J. Demetris, P. Randhawa, A. Jain, A. Tzakis, T. R. Hakala, R. L. Simmons, T. E. Starzl

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 ± 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.

Original languageEnglish (US)
Pages (from-to)669-672
Number of pages4
JournalTransplantation proceedings
Volume25
Issue number1
StatePublished - Mar 8 1993

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Azathioprine
Tacrolimus
Prednisone
Kidney Transplantation
Immunosuppressive Agents
Pharmaceutical Preparations
Graft Survival
Survival

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Shapiro, R., Jordan, M. L., Scantlebury, V. P., Fung, J. J., Jensen, C., Vivas, C., ... Starzl, T. E. (1993). Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report. Transplantation proceedings, 25(1), 669-672.
Shapiro, R. ; Jordan, M. L. ; Scantlebury, V. P. ; Fung, J. J. ; Jensen, C. ; Vivas, C. ; McCauley, J. ; Irish, W. D. ; Mitchell, S. ; Demetris, A. J. ; Randhawa, P. ; Jain, A. ; Tzakis, A. ; Hakala, T. R. ; Simmons, R. L. ; Starzl, T. E. / Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation : Preliminary report. In: Transplantation proceedings. 1993 ; Vol. 25, No. 1. pp. 669-672.
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Shapiro, R, Jordan, ML, Scantlebury, VP, Fung, JJ, Jensen, C, Vivas, C, McCauley, J, Irish, WD, Mitchell, S, Demetris, AJ, Randhawa, P, Jain, A, Tzakis, A, Hakala, TR, Simmons, RL & Starzl, TE 1993, 'Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report', Transplantation proceedings, vol. 25, no. 1, pp. 669-672.

Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation : Preliminary report. / Shapiro, R.; Jordan, M. L.; Scantlebury, V. P.; Fung, J. J.; Jensen, C.; Vivas, C.; McCauley, J.; Irish, W. D.; Mitchell, S.; Demetris, A. J.; Randhawa, P.; Jain, A.; Tzakis, A.; Hakala, T. R.; Simmons, R. L.; Starzl, T. E.

In: Transplantation proceedings, Vol. 25, No. 1, 08.03.1993, p. 669-672.

Research output: Contribution to journalArticle

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Shapiro R, Jordan ML, Scantlebury VP, Fung JJ, Jensen C, Vivas C et al. Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: Preliminary report. Transplantation proceedings. 1993 Mar 8;25(1):669-672.