Rapid divergence and diversification of mammalian duplicate gene functions

Raquel Assis, Doris Bachtrog

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: Gene duplication provides raw material for the evolution of functional innovation. We recently developed a phylogenetic method that classifies evolutionary processes driving the retention of duplicate genes by quantifying divergence between their spatial gene expression profiles and that of their single-copy orthologous gene in a closely related sister species. Results: Here, we apply our classification method to pairs of duplicate genes in eight mammalian genomes, using data from 11 tissues to construct spatial gene expression profiles. We find that young mammalian duplicates are often functionally conserved, and that expression divergence rapidly increases over evolutionary time. Moreover, expression divergence results in increased tissue specificity, with an overrepresentation of expression in male kidney, underrepresentation of expression in female liver, and strong underrepresentation of expression in testis. Thus, duplicate genes acquire a diversity of new tissue-specific functions outside of the testis, possibly contributing to the origin of a multitude of complex phenotypes during mammalian evolution. Conclusions: Our findings reveal that mammalian duplicate genes are initially functionally conserved, and then undergo rapid functional divergence over evolutionary time, acquiring diverse tissue-specific biological roles. These observations are in stark contrast to the much faster expression divergence and acquisition of broad housekeeping roles we previously observed in Drosophila duplicate genes. Due to the smaller effective population sizes of mammals relative to Drosophila, these analyses implicate natural selection in the functional evolution of duplicate genes.

Original languageEnglish (US)
Article number138
JournalBMC Evolutionary Biology
Volume15
Issue number1
DOIs
StatePublished - Jul 15 2015

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Fingerprint Dive into the research topics of 'Rapid divergence and diversification of mammalian duplicate gene functions'. Together they form a unique fingerprint.

Cite this