Rapid loss of nicotine-cholinergic receptor binding activity in the deafferented avian optic lobe

Nicholas Brecha, Andrew Francis, Nisson Schechter

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The levels of α-bungarotoxin (α-BuTX) sensitive receptor sites were investigated in the optic lobe after optic deafferentation in the neonatal and adult chicken. Within two days a 30% loss of α-BuTX binding sites per optic lobe is observed in the neonatal chick after enucleation. The results are similar with the adult chicken in experiments where the receptor binding activity is measured in the optic lobe and in the optic tectum after enucleation. The possibility that acetylcholine is a neurotransmitter in the vertebrate retinotectal pathway is discussed.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalBrain research
Volume167
Issue number2
DOIs
StatePublished - May 11 1979

Fingerprint

Cholinergic Receptors
Nicotine
Chickens
Bungarotoxins
Superior Colliculi
Acetylcholine
Neurotransmitter Agents
Vertebrates
Binding Sites

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

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Rapid loss of nicotine-cholinergic receptor binding activity in the deafferented avian optic lobe. / Brecha, Nicholas; Francis, Andrew; Schechter, Nisson.

In: Brain research, Vol. 167, No. 2, 11.05.1979, p. 273-280.

Research output: Contribution to journalArticle

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