Rapid, Noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test

Gautam Kalyatanda, Kenneth Rand, Martin S. Lindner, David K. Hong, Mehmet Sait Albayram, Jason Gregory, Jesse Kresak, Karim M.Ali Ibne, Jennifer R. Cope, Shantanu Roy, Joy M. Gary, Varalakshmi Reddy, Asim A. Ahmed

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cellfree DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.

Original languageEnglish (US)
Article numberofaa189
JournalOpen Forum Infectious Diseases
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

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