TY - JOUR
T1 - Rapidly progressive osteoarthritis
T2 - Biomechanical considerations
AU - Walker, Eric
AU - Davis, Derik
AU - Mosher, Timothy
PY - 2011/5/1
Y1 - 2011/5/1
N2 - An underlying hypothesis for rapid cartilage loss in patients with osteoarthritis (OA) is that perturbation from normal joint mechanics produces locally high biomechanical strains that exceed the material properties of the tissue, leading to rapid destruction. Several imaging findings are associated with focally high biomechanical forces and thus are potential candidates for predictive biomarkers of rapid OA progression. This article focuses on 3 aspects of knee biomechanics that have potential magnetic resonance imaging correlates, and which may serve as prognostic biomarkers: knee malalignment, meniscal dysfunction, and injury of the osteochondral unit.
AB - An underlying hypothesis for rapid cartilage loss in patients with osteoarthritis (OA) is that perturbation from normal joint mechanics produces locally high biomechanical strains that exceed the material properties of the tissue, leading to rapid destruction. Several imaging findings are associated with focally high biomechanical forces and thus are potential candidates for predictive biomarkers of rapid OA progression. This article focuses on 3 aspects of knee biomechanics that have potential magnetic resonance imaging correlates, and which may serve as prognostic biomarkers: knee malalignment, meniscal dysfunction, and injury of the osteochondral unit.
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U2 - 10.1016/j.mric.2011.02.008
DO - 10.1016/j.mric.2011.02.008
M3 - Review article
C2 - 21665091
AN - SCOPUS:79958219659
VL - 19
SP - 283
EP - 294
JO - Magnetic Resonance Imaging Clinics of North America
JF - Magnetic Resonance Imaging Clinics of North America
SN - 1064-9689
IS - 2
ER -