Ras May Mediate Mammary Cancer Promotion By High Fat

Junxuan Lu, Cheng Jiang, Susan Fontaine, Henry J. Thompson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

High fat consumption has been implicated as a risk factor for breast cancer. Experimental mammary carcinogenesis studies have demonstrated that the effect of high fat consumption is mainly exerted on the postinitiation stage of the disease process. We report data that have resulted in the formulation of a new hypothesis about the effect of dietary fat on mammary carcinogenesis, namely, that it promotes the development of a subpopulation of cells lacking a specific pathogenetic characteristic. In comparison with animals fed a low-fat diet, female Sprague-Dawley rats fed high-fat diets during the promotional stage developed significantly more (number and proportion) 1-methyl-1-nitrosourea-induced mammary adenocarcinomas that did not contain a codon 12 GGA-GAA mutation in the c-Ha-ras protooncogene. The effect was independent of the types of fat fed, i.e., corn oil vs. fish oil. A model is presented to account for the preferential promotional effect of high fat consumption on 1-methyl-1-nitrosourea-initiated mammary epithelial cells. The hypothesis that the level of dietary fat consumed affects the proportion of mammary carcinomas that occur with a particular pathogenetic characteristic, in this case, the presence or absence of α Ha-ras point mutation, has important implications on the direction of future investigations concerning fat and cancer risk.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalNutrition and cancer
Volume23
Issue number3
DOIs
StatePublished - Jan 1 1995

Fingerprint

Fats
Breast Neoplasms
Breast
Dietary Fats
Carcinogenesis
Fat-Restricted Diet
Corn Oil
Fish Oils
High Fat Diet
Point Mutation
Codon
Sprague Dawley Rats
Adenocarcinoma
Epithelial Cells
Mutation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Lu, Junxuan ; Jiang, Cheng ; Fontaine, Susan ; Thompson, Henry J. / Ras May Mediate Mammary Cancer Promotion By High Fat. In: Nutrition and cancer. 1995 ; Vol. 23, No. 3. pp. 283-290.
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Ras May Mediate Mammary Cancer Promotion By High Fat. / Lu, Junxuan; Jiang, Cheng; Fontaine, Susan; Thompson, Henry J.

In: Nutrition and cancer, Vol. 23, No. 3, 01.01.1995, p. 283-290.

Research output: Contribution to journalArticle

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