Rebound insomnia and rebound anxiety: A review

Anthony Kales, Constantin R. Soldatos, Edward Bixler, Joyce D. Kales

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Rebound insomnia and rebound anxiety are clinical conditions related to withdrawal of certain benzodiazepine drugs. Numerous studies of benzodiazepine and nonbenzodiazepine hypnotics conducted in our sleep laboratory demonstrated that rebound insomnia developed following withdrawal from benzodiazepines with a rapid or intermediate elimination rate. Several studies conducted by other investigators also indicated the development of rebound insomnia under similar conditions. Rebound insomnia and rebound anxiety are discussed in terms of their interrelationship, clinical implications, and receptor mechanisms. Evidence suggests that drugs producing rebound insomnia and rebound anxiety also show a more rapid development of tolerance and greater potential for drug dependence than benzodiazepines where the parent compound or its metabolites have a long elimination half-life.

Original languageEnglish (US)
Pages (from-to)121-137
Number of pages17
JournalPharmacology
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1983

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Sleep Initiation and Maintenance Disorders
Benzodiazepines
Anxiety
Hypnotics and Sedatives
Pharmaceutical Preparations
Substance-Related Disorders
Half-Life
Sleep
Research Personnel

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Kales, A., Soldatos, C. R., Bixler, E., & Kales, J. D. (1983). Rebound insomnia and rebound anxiety: A review. Pharmacology, 26(3), 121-137. https://doi.org/10.1159/000137794
Kales, Anthony ; Soldatos, Constantin R. ; Bixler, Edward ; Kales, Joyce D. / Rebound insomnia and rebound anxiety : A review. In: Pharmacology. 1983 ; Vol. 26, No. 3. pp. 121-137.
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Kales, A, Soldatos, CR, Bixler, E & Kales, JD 1983, 'Rebound insomnia and rebound anxiety: A review', Pharmacology, vol. 26, no. 3, pp. 121-137. https://doi.org/10.1159/000137794

Rebound insomnia and rebound anxiety : A review. / Kales, Anthony; Soldatos, Constantin R.; Bixler, Edward; Kales, Joyce D.

In: Pharmacology, Vol. 26, No. 3, 01.01.1983, p. 121-137.

Research output: Contribution to journalArticle

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Kales A, Soldatos CR, Bixler E, Kales JD. Rebound insomnia and rebound anxiety: A review. Pharmacology. 1983 Jan 1;26(3):121-137. https://doi.org/10.1159/000137794