85 Citations (Scopus)

Abstract

Identification of epitopes that invoke strong responses from B-cells is one of the key steps in designing effective vaccines against pathogens. Because experimental determination of epitopes is expensive in terms of cost, time, and effort involved, there is an urgent need for computational methods for reliable identification of B-cell epitopes. Although several computational tools for predicting B-cell epitopes have become available in recent years, the predictive performance of existing tools remains far from ideal. We review recent advances in computational methods for B-cell epitope prediction, identify some gaps in the current state of the art, and outline some promising directions for improving the reliability of such methods.

Original languageEnglish (US)
Article numberS2
JournalImmunome Research
Volume6
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 15 2010

Fingerprint

B-Lymphocyte Epitopes
Epitopes
B Cells
Cells
Prediction
Computational Methods
Computational methods
Vaccine
B-Lymphocytes
Vaccines
Costs and Cost Analysis
Pathogens
Costs

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Applied Mathematics

Cite this

El-Manzalawy, Yasser ; Honavar, Vasant. / Recent advances in B-cell epitope prediction methods. In: Immunome Research. 2010 ; Vol. 6, No. SUPPL. 2.
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Recent advances in B-cell epitope prediction methods. / El-Manzalawy, Yasser; Honavar, Vasant.

In: Immunome Research, Vol. 6, No. SUPPL. 2, S2, 15.11.2010.

Research output: Contribution to journalReview article

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T1 - Recent advances in B-cell epitope prediction methods

AU - El-Manzalawy, Yasser

AU - Honavar, Vasant

PY - 2010/11/15

Y1 - 2010/11/15

N2 - Identification of epitopes that invoke strong responses from B-cells is one of the key steps in designing effective vaccines against pathogens. Because experimental determination of epitopes is expensive in terms of cost, time, and effort involved, there is an urgent need for computational methods for reliable identification of B-cell epitopes. Although several computational tools for predicting B-cell epitopes have become available in recent years, the predictive performance of existing tools remains far from ideal. We review recent advances in computational methods for B-cell epitope prediction, identify some gaps in the current state of the art, and outline some promising directions for improving the reliability of such methods.

AB - Identification of epitopes that invoke strong responses from B-cells is one of the key steps in designing effective vaccines against pathogens. Because experimental determination of epitopes is expensive in terms of cost, time, and effort involved, there is an urgent need for computational methods for reliable identification of B-cell epitopes. Although several computational tools for predicting B-cell epitopes have become available in recent years, the predictive performance of existing tools remains far from ideal. We review recent advances in computational methods for B-cell epitope prediction, identify some gaps in the current state of the art, and outline some promising directions for improving the reliability of such methods.

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