Recent advances in computational protein design

Robert J. Pantazes, Matthew J. Grisewood, Costas D. Maranas

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Proteins are the molecules cells primarily rely on for catalysis, recognition, signaling, defense, locomotion, and structural integrity. Engineering proteins for improved function or new applications is a fast-growing segment of biotechnology and biomedicine. Experimental efforts based on the screening of large mutant libraries have led to many successes but they do not provide quantitative design principles and/or insight into the structural features that underpin the desired function. The computational de novo design of proteins promises to bridge this gap; however, it requires reliable structure prediction, provisions for protein stability, and accurate descriptions of inter-molecule interactions. Studies that successfully meet all these criteria are beginning to emerge including the design of an O 2-binding protein and a novel enzyme that catalyzes a Diels-Alder reaction.

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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