Recent advances in preclinical model systems for papillomaviruses

Neil Christensen, Lynn R. Budgeon, Nancy M. Cladel, Jiafen Hu

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Preclinical model systems to study multiple features of the papillomavirus life cycle have greatly aided our understanding of Human Papillomavirus (HPV) biology, disease progression and treatments. The challenge to studying HPV in hosts is that HPV along with most PVs are both species and tissue restricted. Thus, fundamental properties of HPV viral proteins can be assessed in specialized cell culture systems but host responses that involve innate immunity and host restriction factors requires preclinical surrogate models. Fortunately, there are several well-characterized and new animal models of papillomavirus infections that are available to the PV research community. Old models that continue to have value include canine, bovine and rabbit PV models and new rodent models are in place to better assess host-virus interactions. Questions arise as to the strengths and weaknesses of animal PV models for HPV disease and how accurately these preclinical models predict malignant progression, vaccine efficacy and therapeutic control of HPV-associated disease. In this review, we examine current preclinical models and highlight the strengths and weaknesses of the various models as well as provide an update on new opportunities to study the numerous unknowns that persist in the HPV research field.

Original languageEnglish (US)
Pages (from-to)108-118
Number of pages11
JournalVirus Research
Volume231
DOIs
StatePublished - Mar 2 2017

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Animal Models
Papillomavirus Infections
Viral Proteins
Life Cycle Stages
Research
Innate Immunity
Disease Progression
Canidae
Rodentia
Vaccines
Cell Culture Techniques
Rabbits
Viruses
Therapeutics

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Christensen, Neil ; Budgeon, Lynn R. ; Cladel, Nancy M. ; Hu, Jiafen. / Recent advances in preclinical model systems for papillomaviruses. In: Virus Research. 2017 ; Vol. 231. pp. 108-118.
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Recent advances in preclinical model systems for papillomaviruses. / Christensen, Neil; Budgeon, Lynn R.; Cladel, Nancy M.; Hu, Jiafen.

In: Virus Research, Vol. 231, 02.03.2017, p. 108-118.

Research output: Contribution to journalReview article

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