Recent advances in the reconstruction of metabolic models and integration of omics data

Rajib Saha, Anupam Chowdhury, Costas D. Maranas

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

With the ever-accelerating pace of genome sequencing and annotation information generation, the development of computational pipelines for the rapid reconstruction of high-quality metabolic networks has received significant attention. Herein, we review the available biological databases and automated/semi-automated reconstruction tools. In addition, we describe available methodologies for the integration of high-throughput omics data to increase metabolic phenotype prediction accuracy. Data heterogeneity and lack of better integration of metabolic reconstruction pipelines with omics data generation protocols have hampered rapid progress thus far.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume29
Issue number1
DOIs
StatePublished - Oct 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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