Recent progress and applications in glycosaminoglycan and heparin research

Tatiana Nikolaevna Laremore, Fuming Zhang, Jonathan S. Dordick, Jian Liu, Robert J. Linhardt

Research output: Contribution to journalReview article

80 Scopus citations

Abstract

Heparin, the focus of this review, is a crucially important anticoagulant drug produced from animal sources, which was contaminated last year leading to a number of adverse side effects, some resulting in death. Heparin is a highly acidic polysaccharide and a member of a family of biopolymers called glycosaminoglycans. The structure and activities of heparin are detailed along with recent advances in heparin structural analysis and biological evaluation. Current state-of-the-art chemical and chemoenzymatic synthesis of heparin and new approaches for its metabolic engineering are described. New technologies, including microarrays and digital microfluidics, are proposed for high-throughput synthesis and screening of heparin and for the fabrication of an artificial Golgi.

Original languageEnglish (US)
Pages (from-to)633-640
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume13
Issue number5-6
DOIs
StatePublished - Dec 1 2009

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Analytical Chemistry

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