Recent progress in studies of factors that elicit pancreatic β-cell expansion

Qiu Li, Zhi Chun Lai

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat diabetes would be to enhance the ability of β-cells to increase the mass of functional β-cells. Consequently, much effort has been devoted to identify factors that can effectively induce β-cell expansion. This review focuses on recent reports on small molecules and protein factors that have been shown to promote β-cell expansion.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalProtein and Cell
Volume6
Issue number2
DOIs
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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