Receptor coupling to G proteins

Interactions not affected by lithium

John Ellis, R. H. Lenox

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Receptor-G protein interactions were evaluated according to the abilities of GTP analogs to modulate the affinities of receptor agonists and the abilities of agonists to enhance the dissociation of bound GTPγS. Such interactions were readily observed for α2 adrenergic receptors (platelets) and muscarinic receptors (heart, brainstem, hippocampus, and CHO-K1 cells expressing the m2 subtype). It has been reported that lithium abolishes receptor-G protein communication, but the presence of lithium at and above clinically relevant concentrations did not alter any of these interactions in our studies. In light of these data, investigators should not assume that lithium can be used to evaluate G protein involvement in cellular functions.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalLithium
Volume2
Issue number3
StatePublished - 1991

Fingerprint

Lithium
GTP-Binding Proteins
CHO Cells
Muscarinic Receptors
Guanosine Triphosphate
Adrenergic Receptors
Brain Stem
Hippocampus
Blood Platelets
Research Personnel

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Ellis, John ; Lenox, R. H. / Receptor coupling to G proteins : Interactions not affected by lithium. In: Lithium. 1991 ; Vol. 2, No. 3. pp. 141-147.
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Receptor coupling to G proteins : Interactions not affected by lithium. / Ellis, John; Lenox, R. H.

In: Lithium, Vol. 2, No. 3, 1991, p. 141-147.

Research output: Contribution to journalArticle

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