Receptors for immunoglobulin and complement on human alveolar macrophages

Herbert Reynolds, J. P. Atkinson, H. H. Newball, M. M. Frank

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Specific cell membrane surface receptors for immunoglobulin and complement components were identified by rosette formation on in vitro cultured alveolar macrophages obtained from 24 humans and from rabbits. Respiratory macrophages have easily identified receptors for IgG and the C3b fragment of the third component of complement. A macrophage receptor for the C3d fragment was detected only when purified human complement components were used to form erythrocyte antibody C3 immune complexes but was not detected when whole human serum was used as the source of complement. No IgM cell receptor was identified. Thus, with respect to membrane receptors, alveolar macrophages resemble peripheral blood monocytes. These studies emphasize the importance of using a variety of immune reagents, especially the use of human reagents, to determine correctly these cell receptors.

Original languageEnglish (US)
Pages (from-to)1813-1819
Number of pages7
JournalJournal of Immunology
Volume114
Issue number6
StatePublished - Dec 1 1975

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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