Recognition of the nucleosome by chromatin factors and enzymes

Robert K. McGinty, Song Tan

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Dynamic expression of the genome requires coordinated binding of chromatin factors and enzymes that carry out genome-templated processes. Until recently, the molecular mechanisms governing how these factors and enzymes recognize and act on the fundamental unit of chromatin, the nucleosome core particle, have remained a mystery. A small, yet growing set of structures of the nucleosome in complex with chromatin factors and enzymes highlights the importance of multivalency in defining nucleosome binding and specificity. Many such interactions include an arginine anchor motif, which targets a unique acidic patch on the nucleosome surface. These emerging paradigms for chromatin recognition will be discussed, focusing on several recent structural breakthroughs.

Original languageEnglish (US)
Pages (from-to)54-61
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume37
DOIs
StatePublished - Apr 1 2016

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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