Recombinogenic targeting: A new approach to genomic analysis - A review

Cooduvalli S. Shashikant, Janet L. Carr, Jaya Bhargava, Kevin L. Bentley, Frank H. Ruddle

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Currently, recombinational cloning procedures based upon methods developed for yeast, Saccharomyces cerevisiae, are being exploited for targeted cloning and in-vivo modification of genomic clones. In this review, we will discuss the development of large-insert vectors, homologous recombination-based techniques for cloning and modification, and their application towards functional analysis of genes using transgenic mouse model systems.

Original languageEnglish (US)
Pages (from-to)9-20
Number of pages12
JournalGene
Volume223
Issue number1-2
DOIs
StatePublished - Nov 26 1998

All Science Journal Classification (ASJC) codes

  • Genetics

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