Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

Katherine Belov, Janine E. Deakin, Anthony T. Papenfuss, Michelle L. Baker, Sandra D. Melman, Hannah V. Siddle, Nicolas Gouin, David L. Goode, Tobias J. Sargeant, Mark D. Robinson, Matthew J. Wakefield, Shaun A. Mahony, Joseph G.R. Cross, Panayiotis V. Benos, Paul B. Samollow, Terence P. Speed, Jennifer A. Marshall Graves, Robert D. Miller

Research output: Contribution to journalArticle

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Abstract

The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral "immune supercomplex" that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Copyright:

Original languageEnglish (US)
Pages (from-to)317-328
Number of pages12
JournalPLoS biology
Volume4
Issue number3
DOIs
StatePublished - Mar 1 2006

Fingerprint

Marsupialia
major histocompatibility complex
Metatheria
Major Histocompatibility Complex
Genes
opossums
Monodelphis
Genome
Opossums
genome
genes
Mammals
mammals
Monodelphis domestica
MHC Class I Genes
Antigen Presentation
Birds
Immunity
immunity
Organizations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Belov, K., Deakin, J. E., Papenfuss, A. T., Baker, M. L., Melman, S. D., Siddle, H. V., ... Miller, R. D. (2006). Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS biology, 4(3), 317-328. https://doi.org/10.1371/journal.pbio.0040046
Belov, Katherine ; Deakin, Janine E. ; Papenfuss, Anthony T. ; Baker, Michelle L. ; Melman, Sandra D. ; Siddle, Hannah V. ; Gouin, Nicolas ; Goode, David L. ; Sargeant, Tobias J. ; Robinson, Mark D. ; Wakefield, Matthew J. ; Mahony, Shaun A. ; Cross, Joseph G.R. ; Benos, Panayiotis V. ; Samollow, Paul B. ; Speed, Terence P. ; Marshall Graves, Jennifer A. ; Miller, Robert D. / Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. In: PLoS biology. 2006 ; Vol. 4, No. 3. pp. 317-328.
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Belov, K, Deakin, JE, Papenfuss, AT, Baker, ML, Melman, SD, Siddle, HV, Gouin, N, Goode, DL, Sargeant, TJ, Robinson, MD, Wakefield, MJ, Mahony, SA, Cross, JGR, Benos, PV, Samollow, PB, Speed, TP, Marshall Graves, JA & Miller, RD 2006, 'Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex', PLoS biology, vol. 4, no. 3, pp. 317-328. https://doi.org/10.1371/journal.pbio.0040046

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. / Belov, Katherine; Deakin, Janine E.; Papenfuss, Anthony T.; Baker, Michelle L.; Melman, Sandra D.; Siddle, Hannah V.; Gouin, Nicolas; Goode, David L.; Sargeant, Tobias J.; Robinson, Mark D.; Wakefield, Matthew J.; Mahony, Shaun A.; Cross, Joseph G.R.; Benos, Panayiotis V.; Samollow, Paul B.; Speed, Terence P.; Marshall Graves, Jennifer A.; Miller, Robert D.

In: PLoS biology, Vol. 4, No. 3, 01.03.2006, p. 317-328.

Research output: Contribution to journalArticle

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AU - Belov, Katherine

AU - Deakin, Janine E.

AU - Papenfuss, Anthony T.

AU - Baker, Michelle L.

AU - Melman, Sandra D.

AU - Siddle, Hannah V.

AU - Gouin, Nicolas

AU - Goode, David L.

AU - Sargeant, Tobias J.

AU - Robinson, Mark D.

AU - Wakefield, Matthew J.

AU - Mahony, Shaun A.

AU - Cross, Joseph G.R.

AU - Benos, Panayiotis V.

AU - Samollow, Paul B.

AU - Speed, Terence P.

AU - Marshall Graves, Jennifer A.

AU - Miller, Robert D.

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