Reconstructing the Deep Population History of Central and South America

Cosimo Posth, Nathan Nakatsuka, Iosif Lazaridis, Pontus Skoglund, Swapan Mallick, Thiseas C. Lamnidis, Nadin Rohland, Kathrin Nägele, Nicole Adamski, Emilie Bertolini, Nasreen Broomandkhoshbacht, Alan Cooper, Brendan James Culleton, Tiago Ferraz, Matthew Ferry, Anja Furtwängler, Wolfgang Haak, Kelly Harkins, Thomas K. Harper, Tábita Hünemeier & 52 others Ann Marie Lawson, Bastien Llamas, Megan Michel, Elizabeth Nelson, Jonas Oppenheimer, Nick Patterson, Stephan Schiffels, Jakob Sedig, Kristin Stewardson, Sahra Talamo, Chuan Chao Wang, Jean Jacques Hublin, Mark Hubbe, Katerina Harvati, Amalia Nuevo Delaunay, Judith Beier, Michael Francken, Peter Kaulicke, Hugo Reyes-Centeno, Kurt Rademaker, Willa R. Trask, Mark Robinson, Said M. Gutierrez, Keith M. Prufer, Domingo C. Salazar-García, Eliane N. Chim, Lisiane Müller Plumm Gomes, Marcony L. Alves, Andersen Liryo, Mariana Inglez, Rodrigo E. Oliveira, Danilo V. Bernardo, Alberto Barioni, Veronica Wesolowski, Nahuel A. Scheifler, Mario A. Rivera, Claudia R. Plens, Pablo G. Messineo, Levy Figuti, Daniel Corach, Clara Scabuzzo, Sabine Eggers, Paulo DeBlasis, Markus Reindel, César Méndez, Gustavo Politis, Elsa Tomasto-Cagigao, Douglas James Kennett, André Strauss, Lars Fehren-Schmitz, Johannes Krause, David Reich

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report genome-wide ancient DNA from 49 individuals forming four parallel time transects in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least ∼9,000 years ago. The common ancestral population radiated rapidly from just one of the two early branches that contributed to Native Americans today. We document two previously unappreciated streams of gene flow between North and South America. One affected the Central Andes by ∼4,200 years ago, while the other explains an affinity between the oldest North American genome associated with the Clovis culture and the oldest Central and South Americans from Chile, Brazil, and Belize. However, this was not the primary source for later South Americans, as the other ancient individuals derive from lineages without specific affinity to the Clovis-associated genome, suggesting a population replacement that began at least 9,000 years ago and was followed by substantial population continuity in multiple regions. A large-scale analysis of ancient genomes from Central and South America yields insights into the peopling of the Americas, including four southward population spreads and notable population continuity in much of South America after arrival.

Original languageEnglish (US)
Pages (from-to)1185-1197.e22
JournalCell
Volume175
Issue number5
DOIs
StatePublished - Nov 15 2018

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Central America
South America
Belize
Genes
Genome
Population
Brazil
Gene Flow
North American Indians
Chile
Population Dynamics
North America
Cell culture
Cones
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Posth, C., Nakatsuka, N., Lazaridis, I., Skoglund, P., Mallick, S., Lamnidis, T. C., ... Reich, D. (2018). Reconstructing the Deep Population History of Central and South America. Cell, 175(5), 1185-1197.e22. https://doi.org/10.1016/j.cell.2018.10.027
Posth, Cosimo ; Nakatsuka, Nathan ; Lazaridis, Iosif ; Skoglund, Pontus ; Mallick, Swapan ; Lamnidis, Thiseas C. ; Rohland, Nadin ; Nägele, Kathrin ; Adamski, Nicole ; Bertolini, Emilie ; Broomandkhoshbacht, Nasreen ; Cooper, Alan ; Culleton, Brendan James ; Ferraz, Tiago ; Ferry, Matthew ; Furtwängler, Anja ; Haak, Wolfgang ; Harkins, Kelly ; Harper, Thomas K. ; Hünemeier, Tábita ; Lawson, Ann Marie ; Llamas, Bastien ; Michel, Megan ; Nelson, Elizabeth ; Oppenheimer, Jonas ; Patterson, Nick ; Schiffels, Stephan ; Sedig, Jakob ; Stewardson, Kristin ; Talamo, Sahra ; Wang, Chuan Chao ; Hublin, Jean Jacques ; Hubbe, Mark ; Harvati, Katerina ; Nuevo Delaunay, Amalia ; Beier, Judith ; Francken, Michael ; Kaulicke, Peter ; Reyes-Centeno, Hugo ; Rademaker, Kurt ; Trask, Willa R. ; Robinson, Mark ; Gutierrez, Said M. ; Prufer, Keith M. ; Salazar-García, Domingo C. ; Chim, Eliane N. ; Müller Plumm Gomes, Lisiane ; Alves, Marcony L. ; Liryo, Andersen ; Inglez, Mariana ; Oliveira, Rodrigo E. ; Bernardo, Danilo V. ; Barioni, Alberto ; Wesolowski, Veronica ; Scheifler, Nahuel A. ; Rivera, Mario A. ; Plens, Claudia R. ; Messineo, Pablo G. ; Figuti, Levy ; Corach, Daniel ; Scabuzzo, Clara ; Eggers, Sabine ; DeBlasis, Paulo ; Reindel, Markus ; Méndez, César ; Politis, Gustavo ; Tomasto-Cagigao, Elsa ; Kennett, Douglas James ; Strauss, André ; Fehren-Schmitz, Lars ; Krause, Johannes ; Reich, David. / Reconstructing the Deep Population History of Central and South America. In: Cell. 2018 ; Vol. 175, No. 5. pp. 1185-1197.e22.
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abstract = "We report genome-wide ancient DNA from 49 individuals forming four parallel time transects in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least ∼9,000 years ago. The common ancestral population radiated rapidly from just one of the two early branches that contributed to Native Americans today. We document two previously unappreciated streams of gene flow between North and South America. One affected the Central Andes by ∼4,200 years ago, while the other explains an affinity between the oldest North American genome associated with the Clovis culture and the oldest Central and South Americans from Chile, Brazil, and Belize. However, this was not the primary source for later South Americans, as the other ancient individuals derive from lineages without specific affinity to the Clovis-associated genome, suggesting a population replacement that began at least 9,000 years ago and was followed by substantial population continuity in multiple regions. A large-scale analysis of ancient genomes from Central and South America yields insights into the peopling of the Americas, including four southward population spreads and notable population continuity in much of South America after arrival.",
author = "Cosimo Posth and Nathan Nakatsuka and Iosif Lazaridis and Pontus Skoglund and Swapan Mallick and Lamnidis, {Thiseas C.} and Nadin Rohland and Kathrin N{\"a}gele and Nicole Adamski and Emilie Bertolini and Nasreen Broomandkhoshbacht and Alan Cooper and Culleton, {Brendan James} and Tiago Ferraz and Matthew Ferry and Anja Furtw{\"a}ngler and Wolfgang Haak and Kelly Harkins and Harper, {Thomas K.} and T{\'a}bita H{\"u}nemeier and Lawson, {Ann Marie} and Bastien Llamas and Megan Michel and Elizabeth Nelson and Jonas Oppenheimer and Nick Patterson and Stephan Schiffels and Jakob Sedig and Kristin Stewardson and Sahra Talamo and Wang, {Chuan Chao} and Hublin, {Jean Jacques} and Mark Hubbe and Katerina Harvati and {Nuevo Delaunay}, Amalia and Judith Beier and Michael Francken and Peter Kaulicke and Hugo Reyes-Centeno and Kurt Rademaker and Trask, {Willa R.} and Mark Robinson and Gutierrez, {Said M.} and Prufer, {Keith M.} and Salazar-Garc{\'i}a, {Domingo C.} and Chim, {Eliane N.} and {M{\"u}ller Plumm Gomes}, Lisiane and Alves, {Marcony L.} and Andersen Liryo and Mariana Inglez and Oliveira, {Rodrigo E.} and Bernardo, {Danilo V.} and Alberto Barioni and Veronica Wesolowski and Scheifler, {Nahuel A.} and Rivera, {Mario A.} and Plens, {Claudia R.} and Messineo, {Pablo G.} and Levy Figuti and Daniel Corach and Clara Scabuzzo and Sabine Eggers and Paulo DeBlasis and Markus Reindel and C{\'e}sar M{\'e}ndez and Gustavo Politis and Elsa Tomasto-Cagigao and Kennett, {Douglas James} and Andr{\'e} Strauss and Lars Fehren-Schmitz and Johannes Krause and David Reich",
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Posth, C, Nakatsuka, N, Lazaridis, I, Skoglund, P, Mallick, S, Lamnidis, TC, Rohland, N, Nägele, K, Adamski, N, Bertolini, E, Broomandkhoshbacht, N, Cooper, A, Culleton, BJ, Ferraz, T, Ferry, M, Furtwängler, A, Haak, W, Harkins, K, Harper, TK, Hünemeier, T, Lawson, AM, Llamas, B, Michel, M, Nelson, E, Oppenheimer, J, Patterson, N, Schiffels, S, Sedig, J, Stewardson, K, Talamo, S, Wang, CC, Hublin, JJ, Hubbe, M, Harvati, K, Nuevo Delaunay, A, Beier, J, Francken, M, Kaulicke, P, Reyes-Centeno, H, Rademaker, K, Trask, WR, Robinson, M, Gutierrez, SM, Prufer, KM, Salazar-García, DC, Chim, EN, Müller Plumm Gomes, L, Alves, ML, Liryo, A, Inglez, M, Oliveira, RE, Bernardo, DV, Barioni, A, Wesolowski, V, Scheifler, NA, Rivera, MA, Plens, CR, Messineo, PG, Figuti, L, Corach, D, Scabuzzo, C, Eggers, S, DeBlasis, P, Reindel, M, Méndez, C, Politis, G, Tomasto-Cagigao, E, Kennett, DJ, Strauss, A, Fehren-Schmitz, L, Krause, J & Reich, D 2018, 'Reconstructing the Deep Population History of Central and South America', Cell, vol. 175, no. 5, pp. 1185-1197.e22. https://doi.org/10.1016/j.cell.2018.10.027

Reconstructing the Deep Population History of Central and South America. / Posth, Cosimo; Nakatsuka, Nathan; Lazaridis, Iosif; Skoglund, Pontus; Mallick, Swapan; Lamnidis, Thiseas C.; Rohland, Nadin; Nägele, Kathrin; Adamski, Nicole; Bertolini, Emilie; Broomandkhoshbacht, Nasreen; Cooper, Alan; Culleton, Brendan James; Ferraz, Tiago; Ferry, Matthew; Furtwängler, Anja; Haak, Wolfgang; Harkins, Kelly; Harper, Thomas K.; Hünemeier, Tábita; Lawson, Ann Marie; Llamas, Bastien; Michel, Megan; Nelson, Elizabeth; Oppenheimer, Jonas; Patterson, Nick; Schiffels, Stephan; Sedig, Jakob; Stewardson, Kristin; Talamo, Sahra; Wang, Chuan Chao; Hublin, Jean Jacques; Hubbe, Mark; Harvati, Katerina; Nuevo Delaunay, Amalia; Beier, Judith; Francken, Michael; Kaulicke, Peter; Reyes-Centeno, Hugo; Rademaker, Kurt; Trask, Willa R.; Robinson, Mark; Gutierrez, Said M.; Prufer, Keith M.; Salazar-García, Domingo C.; Chim, Eliane N.; Müller Plumm Gomes, Lisiane; Alves, Marcony L.; Liryo, Andersen; Inglez, Mariana; Oliveira, Rodrigo E.; Bernardo, Danilo V.; Barioni, Alberto; Wesolowski, Veronica; Scheifler, Nahuel A.; Rivera, Mario A.; Plens, Claudia R.; Messineo, Pablo G.; Figuti, Levy; Corach, Daniel; Scabuzzo, Clara; Eggers, Sabine; DeBlasis, Paulo; Reindel, Markus; Méndez, César; Politis, Gustavo; Tomasto-Cagigao, Elsa; Kennett, Douglas James; Strauss, André; Fehren-Schmitz, Lars; Krause, Johannes; Reich, David.

In: Cell, Vol. 175, No. 5, 15.11.2018, p. 1185-1197.e22.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reconstructing the Deep Population History of Central and South America

AU - Posth, Cosimo

AU - Nakatsuka, Nathan

AU - Lazaridis, Iosif

AU - Skoglund, Pontus

AU - Mallick, Swapan

AU - Lamnidis, Thiseas C.

AU - Rohland, Nadin

AU - Nägele, Kathrin

AU - Adamski, Nicole

AU - Bertolini, Emilie

AU - Broomandkhoshbacht, Nasreen

AU - Cooper, Alan

AU - Culleton, Brendan James

AU - Ferraz, Tiago

AU - Ferry, Matthew

AU - Furtwängler, Anja

AU - Haak, Wolfgang

AU - Harkins, Kelly

AU - Harper, Thomas K.

AU - Hünemeier, Tábita

AU - Lawson, Ann Marie

AU - Llamas, Bastien

AU - Michel, Megan

AU - Nelson, Elizabeth

AU - Oppenheimer, Jonas

AU - Patterson, Nick

AU - Schiffels, Stephan

AU - Sedig, Jakob

AU - Stewardson, Kristin

AU - Talamo, Sahra

AU - Wang, Chuan Chao

AU - Hublin, Jean Jacques

AU - Hubbe, Mark

AU - Harvati, Katerina

AU - Nuevo Delaunay, Amalia

AU - Beier, Judith

AU - Francken, Michael

AU - Kaulicke, Peter

AU - Reyes-Centeno, Hugo

AU - Rademaker, Kurt

AU - Trask, Willa R.

AU - Robinson, Mark

AU - Gutierrez, Said M.

AU - Prufer, Keith M.

AU - Salazar-García, Domingo C.

AU - Chim, Eliane N.

AU - Müller Plumm Gomes, Lisiane

AU - Alves, Marcony L.

AU - Liryo, Andersen

AU - Inglez, Mariana

AU - Oliveira, Rodrigo E.

AU - Bernardo, Danilo V.

AU - Barioni, Alberto

AU - Wesolowski, Veronica

AU - Scheifler, Nahuel A.

AU - Rivera, Mario A.

AU - Plens, Claudia R.

AU - Messineo, Pablo G.

AU - Figuti, Levy

AU - Corach, Daniel

AU - Scabuzzo, Clara

AU - Eggers, Sabine

AU - DeBlasis, Paulo

AU - Reindel, Markus

AU - Méndez, César

AU - Politis, Gustavo

AU - Tomasto-Cagigao, Elsa

AU - Kennett, Douglas James

AU - Strauss, André

AU - Fehren-Schmitz, Lars

AU - Krause, Johannes

AU - Reich, David

PY - 2018/11/15

Y1 - 2018/11/15

N2 - We report genome-wide ancient DNA from 49 individuals forming four parallel time transects in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least ∼9,000 years ago. The common ancestral population radiated rapidly from just one of the two early branches that contributed to Native Americans today. We document two previously unappreciated streams of gene flow between North and South America. One affected the Central Andes by ∼4,200 years ago, while the other explains an affinity between the oldest North American genome associated with the Clovis culture and the oldest Central and South Americans from Chile, Brazil, and Belize. However, this was not the primary source for later South Americans, as the other ancient individuals derive from lineages without specific affinity to the Clovis-associated genome, suggesting a population replacement that began at least 9,000 years ago and was followed by substantial population continuity in multiple regions. A large-scale analysis of ancient genomes from Central and South America yields insights into the peopling of the Americas, including four southward population spreads and notable population continuity in much of South America after arrival.

AB - We report genome-wide ancient DNA from 49 individuals forming four parallel time transects in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least ∼9,000 years ago. The common ancestral population radiated rapidly from just one of the two early branches that contributed to Native Americans today. We document two previously unappreciated streams of gene flow between North and South America. One affected the Central Andes by ∼4,200 years ago, while the other explains an affinity between the oldest North American genome associated with the Clovis culture and the oldest Central and South Americans from Chile, Brazil, and Belize. However, this was not the primary source for later South Americans, as the other ancient individuals derive from lineages without specific affinity to the Clovis-associated genome, suggesting a population replacement that began at least 9,000 years ago and was followed by substantial population continuity in multiple regions. A large-scale analysis of ancient genomes from Central and South America yields insights into the peopling of the Americas, including four southward population spreads and notable population continuity in much of South America after arrival.

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DO - 10.1016/j.cell.2018.10.027

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Posth C, Nakatsuka N, Lazaridis I, Skoglund P, Mallick S, Lamnidis TC et al. Reconstructing the Deep Population History of Central and South America. Cell. 2018 Nov 15;175(5):1185-1197.e22. https://doi.org/10.1016/j.cell.2018.10.027