Reconstructing the evolutionary history of complex human gene clusters

Yu Zhang, Giltae Song, Tomáš Vinař, Eric D. Green, Adam Siepel, Webb Miller

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

Clusters of genes that evolved from single progenitors via repeated segmental duplications present significant challenges to the generation of a truly complete human genome sequence. Such clusters can confound both accurate sequence assembly and downstream computational analysis, yet they represent a hotbed of functional innovation, making them of extreme interest. We have developed an algorithm for reconstructing the evolutionary history of gene clusters using only human genomic sequence data. This method allows the tempo of large-scale evolutionary events in human gene clusters to be estimated, which in turn will facilitate primate comparative sequencing studies that will aim to reconstruct their evolutionary history more fully.

Original languageEnglish (US)
Title of host publicationResearch in Computational Molecular Biology - 12th Annual International Conference, RECOMB 2008, Proceedings
Pages29-49
Number of pages21
DOIs
StatePublished - Jul 21 2008
Event"12th Annual InternationalConference on REsearch in COmputational Molecular Biology, RECOMB 2008" - Singapore, Singapore
Duration: Mar 30 2008Apr 2 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4955 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other"12th Annual InternationalConference on REsearch in COmputational Molecular Biology, RECOMB 2008"
CountrySingapore
CitySingapore
Period3/30/084/2/08

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All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Zhang, Y., Song, G., Vinař, T., Green, E. D., Siepel, A., & Miller, W. (2008). Reconstructing the evolutionary history of complex human gene clusters. In Research in Computational Molecular Biology - 12th Annual International Conference, RECOMB 2008, Proceedings (pp. 29-49). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4955 LNBI). https://doi.org/10.1007/978-3-540-78839-3_4