Recovering 3D tumor locations from 2D bioluminescence images and registration with CT images

Xiaolei Huang, Dimitris N. Metaxas, Lata G. Menon, Philipp Mayer-Kuckuk, Joseph R. Bertino, Debabrata Banerjee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we introduce a novel and efficient algorithm for reconstructing the 3D locations of tumor sites from a set of 2D bioluminescence images which are taken by a same camera but after continually rotating the object by a small angle. Our approach requires a much simpler set up than those using multiple cameras, and the algorithmic steps in our framework are efficient and robust enough to facilitate its use in analyzing the repeated imaging of a same animal transplanted with gene marked cells. In order to visualize in 3D the structure of the tumor, we also co-register the BLI-reconstructed crude structure with detailed anatomical structure extracted from high-resolution microCT on a single platform. We present our method using both phantom studies and real studies on small animals.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
DOIs
StatePublished - May 11 2006
EventMultimodal Biomedical Imaging - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6081
ISSN (Print)0277-786X

Conference

ConferenceMultimodal Biomedical Imaging
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Huang, X., Metaxas, D. N., Menon, L. G., Mayer-Kuckuk, P., Bertino, J. R., & Banerjee, D. (2006). Recovering 3D tumor locations from 2D bioluminescence images and registration with CT images. In Proceedings of SPIE - The International Society for Optical Engineering [60810B] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6081). https://doi.org/10.1117/12.647662