Recovery of tectal nicotinic-cholinergic receptor sites during optic nerve regeneration in goldfish

Nisson Schechter, Andrew Francis, Dale G. Deutsch, Michael S. Gazzaniga

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The concentration of cholinergic nicotinic-like sites as measured by alphabungarotoxin (αBuTX) binding, decreased in the goldfish (Carassius auratus) optic tectum after optic nerve disconnection. Initially, the rate of loss of sites is greater than the rate of tissue or protein degradation in experiments where disconnection was achieved either by unilateral optic nerve crush or by enucleation of one eye. When the crushed optic nerve is allowed to regenerate and form behaviorally potent connections, the number and concentration of these sites appears restored. Pharmacological studies indicate that the αBuTX binding site in the goldfish optic tectum has a drug binding profile similar to that seen at central or peripheral αBuTX sites in other species.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalBrain research
Volume166
Issue number1
DOIs
StatePublished - Apr 20 1979

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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