Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Nicola Nicolotti, Shu Chun Chuang, Gabriella Cadoni, Dario Arzani, Livia Petrelli, Cristina Bosetti, Hermann Brenner, Satoyo Hosono, Carlo La Vecchia, Keitaro Matsuo, Heiko Müller, Joshua Muscat, Gaetano Paludetti, Gualtiero Ricciardi, Paolo Boffetta, Mia Hashibe, Stefania Boccia

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Abstract

Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22% lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95% Confidence Interval (95% CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95% CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95% CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95% CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95% CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95% CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95% CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95% CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95% CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95% CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.

Original languageEnglish (US)
Pages (from-to)619-628
Number of pages10
JournalEuropean Journal of Epidemiology
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2011

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Head and Neck Neoplasms
Epidemiology
Odds Ratio
Confidence Intervals
Pharyngeal Neoplasms
Laryngeal Neoplasms
Pharynx
Mouth
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Nicolotti, Nicola ; Chuang, Shu Chun ; Cadoni, Gabriella ; Arzani, Dario ; Petrelli, Livia ; Bosetti, Cristina ; Brenner, Hermann ; Hosono, Satoyo ; La Vecchia, Carlo ; Matsuo, Keitaro ; Müller, Heiko ; Muscat, Joshua ; Paludetti, Gaetano ; Ricciardi, Gualtiero ; Boffetta, Paolo ; Hashibe, Mia ; Boccia, Stefania. / Recreational physical activity and risk of head and neck cancer : A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium. In: European Journal of Epidemiology. 2011 ; Vol. 26, No. 8. pp. 619-628.
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title = "Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium",
abstract = "Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22{\%} lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95{\%} Confidence Interval (95{\%} CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95{\%} CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95{\%} CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95{\%} CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95{\%} CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95{\%} CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95{\%} CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95{\%} CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95{\%} CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95{\%} CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.",
author = "Nicola Nicolotti and Chuang, {Shu Chun} and Gabriella Cadoni and Dario Arzani and Livia Petrelli and Cristina Bosetti and Hermann Brenner and Satoyo Hosono and {La Vecchia}, Carlo and Keitaro Matsuo and Heiko M{\"u}ller and Joshua Muscat and Gaetano Paludetti and Gualtiero Ricciardi and Paolo Boffetta and Mia Hashibe and Stefania Boccia",
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Nicolotti, N, Chuang, SC, Cadoni, G, Arzani, D, Petrelli, L, Bosetti, C, Brenner, H, Hosono, S, La Vecchia, C, Matsuo, K, Müller, H, Muscat, J, Paludetti, G, Ricciardi, G, Boffetta, P, Hashibe, M & Boccia, S 2011, 'Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium', European Journal of Epidemiology, vol. 26, no. 8, pp. 619-628. https://doi.org/10.1007/s10654-011-9612-3

Recreational physical activity and risk of head and neck cancer : A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium. / Nicolotti, Nicola; Chuang, Shu Chun; Cadoni, Gabriella; Arzani, Dario; Petrelli, Livia; Bosetti, Cristina; Brenner, Hermann; Hosono, Satoyo; La Vecchia, Carlo; Matsuo, Keitaro; Müller, Heiko; Muscat, Joshua; Paludetti, Gaetano; Ricciardi, Gualtiero; Boffetta, Paolo; Hashibe, Mia; Boccia, Stefania.

In: European Journal of Epidemiology, Vol. 26, No. 8, 01.08.2011, p. 619-628.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recreational physical activity and risk of head and neck cancer

T2 - A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

AU - Nicolotti, Nicola

AU - Chuang, Shu Chun

AU - Cadoni, Gabriella

AU - Arzani, Dario

AU - Petrelli, Livia

AU - Bosetti, Cristina

AU - Brenner, Hermann

AU - Hosono, Satoyo

AU - La Vecchia, Carlo

AU - Matsuo, Keitaro

AU - Müller, Heiko

AU - Muscat, Joshua

AU - Paludetti, Gaetano

AU - Ricciardi, Gualtiero

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Boccia, Stefania

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22% lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95% Confidence Interval (95% CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95% CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95% CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95% CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95% CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95% CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95% CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95% CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95% CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95% CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.

AB - Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22% lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95% Confidence Interval (95% CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95% CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95% CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95% CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95% CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95% CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95% CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95% CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95% CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95% CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.

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