Recruitment of transcription complexes to enhancers and the role of enhancer transcription

Jared S. Stees, Fred Varn, Suming Huang, John Strouboulis, Jörg Bungert

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

Original languageEnglish (US)
Pages (from-to)778-793
Number of pages16
JournalBiology
Volume1
Issue number3
DOIs
StatePublished - Dec 5 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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