Recruitment of transcription complexes to enhancers and the role of enhancer transcription

Jared S. Stees, Fred Varn, Suming Huang, John Strouboulis, Jörg Bungert

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

Original languageEnglish (US)
Pages (from-to)778-793
Number of pages16
JournalBiology
Volume1
Issue number3
DOIs
StatePublished - Dec 5 2012

Fingerprint

RNA Polymerase II
Gene Expression Regulation
Transcription
transcription (genetics)
Gene Expression
enhancer elements
gene expression regulation
DNA-directed RNA polymerase
Gene expression
Genes
Cells
developmental stages
Tissue
gene expression
cells
tissues

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Stees, Jared S. ; Varn, Fred ; Huang, Suming ; Strouboulis, John ; Bungert, Jörg. / Recruitment of transcription complexes to enhancers and the role of enhancer transcription. In: Biology. 2012 ; Vol. 1, No. 3. pp. 778-793.
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Recruitment of transcription complexes to enhancers and the role of enhancer transcription. / Stees, Jared S.; Varn, Fred; Huang, Suming; Strouboulis, John; Bungert, Jörg.

In: Biology, Vol. 1, No. 3, 05.12.2012, p. 778-793.

Research output: Contribution to journalReview article

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AU - Stees, Jared S.

AU - Varn, Fred

AU - Huang, Suming

AU - Strouboulis, John

AU - Bungert, Jörg

PY - 2012/12/5

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N2 - Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.

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