Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity

Mary Jeanne Kreek; Marvin H. Sleisenger; Graham H. Jeffries

doi:10.1016/0002-9343(67)90122-2

Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity

Mary Jeanne Kreek, Marvin H. Sleisenger, Graham H. Jeffries

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Described herein is a patient with cholestatic jaundice which recurred during each of eight (or nine) pregnancies. Similar episodes of jaundice were associated with abnormal menses (menorrhagia). Following delivery or with the onset of menstruation the patient became asymptomatic, and liver function returned to normal. Liver biopsies showed intrahepatic cholestasis during pregnancy, and a return to normal after pregnancy. An identical clinical picture with jaundice and abnormal liver function tests was induced when the patient was challenged with the synthetic estrogen, estinyl estradiol (1 mg. daily). This patient is presented as a case of idiopathic recurrent cholestatic jaundice of pregnancy. The evidence that this entity may have a hormonal basis is discussed.

Original language	English (US)
Pages (from-to)	795-803
Number of pages	9
Journal	The American journal of medicine
Volume	43
Issue number	5
DOIs	https://doi.org/10.1016/0002-9343(67)90122-2
State	Published - Nov 1967

All Science Journal Classification (ASJC) codes

Medicine(all)

Access to Document

10.1016/0002-9343(67)90122-2

Fingerprint Dive into the research topics of 'Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity'. Together they form a unique fingerprint.

Cite this

@article{db0064dec8194530ab861481b202775b,

title = "Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity",

abstract = "Described herein is a patient with cholestatic jaundice which recurred during each of eight (or nine) pregnancies. Similar episodes of jaundice were associated with abnormal menses (menorrhagia). Following delivery or with the onset of menstruation the patient became asymptomatic, and liver function returned to normal. Liver biopsies showed intrahepatic cholestasis during pregnancy, and a return to normal after pregnancy. An identical clinical picture with jaundice and abnormal liver function tests was induced when the patient was challenged with the synthetic estrogen, estinyl estradiol (1 mg. daily). This patient is presented as a case of idiopathic recurrent cholestatic jaundice of pregnancy. The evidence that this entity may have a hormonal basis is discussed.",

author = "Kreek, {Mary Jeanne} and Sleisenger, {Marvin H.} and Jeffries, {Graham H.}",

note = "Funding Information: * From the Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, New York. Requests for reprints should be addressed to Dr. Mary Jeanne Kreek, New York Hospital, 525 E. 68th Street, New York, New York 10021. Manuscript received November 4, 1966. t Supported by a Postdoctoral Research Fellowship, U. S. Public Health Service F2 A.M. - 30, 036. $ Recipient of Research Career Development Award, U. S. Public Health Service 5 K3-AM-14, 153.",

year = "1967",

month = nov,

doi = "10.1016/0002-9343(67)90122-2",

language = "English (US)",

volume = "43",

pages = "795--803",

journal = "American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity

AU - Kreek, Mary Jeanne

AU - Sleisenger, Marvin H.

AU - Jeffries, Graham H.

N1 - Funding Information: * From the Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, New York. Requests for reprints should be addressed to Dr. Mary Jeanne Kreek, New York Hospital, 525 E. 68th Street, New York, New York 10021. Manuscript received November 4, 1966. t Supported by a Postdoctoral Research Fellowship, U. S. Public Health Service F2 A.M. - 30, 036. $ Recipient of Research Career Development Award, U. S. Public Health Service 5 K3-AM-14, 153.

PY - 1967/11

Y1 - 1967/11

N2 - Described herein is a patient with cholestatic jaundice which recurred during each of eight (or nine) pregnancies. Similar episodes of jaundice were associated with abnormal menses (menorrhagia). Following delivery or with the onset of menstruation the patient became asymptomatic, and liver function returned to normal. Liver biopsies showed intrahepatic cholestasis during pregnancy, and a return to normal after pregnancy. An identical clinical picture with jaundice and abnormal liver function tests was induced when the patient was challenged with the synthetic estrogen, estinyl estradiol (1 mg. daily). This patient is presented as a case of idiopathic recurrent cholestatic jaundice of pregnancy. The evidence that this entity may have a hormonal basis is discussed.

AB - Described herein is a patient with cholestatic jaundice which recurred during each of eight (or nine) pregnancies. Similar episodes of jaundice were associated with abnormal menses (menorrhagia). Following delivery or with the onset of menstruation the patient became asymptomatic, and liver function returned to normal. Liver biopsies showed intrahepatic cholestasis during pregnancy, and a return to normal after pregnancy. An identical clinical picture with jaundice and abnormal liver function tests was induced when the patient was challenged with the synthetic estrogen, estinyl estradiol (1 mg. daily). This patient is presented as a case of idiopathic recurrent cholestatic jaundice of pregnancy. The evidence that this entity may have a hormonal basis is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0014147840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014147840&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(67)90122-2

DO - 10.1016/0002-9343(67)90122-2

M3 - Article

C2 - 6054843

AN - SCOPUS:0014147840

VL - 43

SP - 795

EP - 803

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 5

ER -

Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this