Recurrent Episodes of Stroke-Like Symptoms in a Patient with Charcot-Marie-Tooth Neuropathy X Type 1

Ning Wu, Sarita Said, Shyamsunder Sabat, Matthew Wicklund, Mark C. Stahl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Charcot-Marie-Tooth disease (CMT), also known as hereditary motor sensory neuropathy, is a heterogeneous group of disorders best known for causing inherited forms of peripheral neuropathy. The X-linked form, CMTX1, is caused by mutations in the gap junction protein beta 1 (GJB1) gene, expressed both by peripheral Schwann cells and central oligodendrocytes. Central manifestations are known but are rare, and there are few case reports of leukoencephalopathy with transient or persistent neurological deficits in patients with this CMT subtype. Here, we report the case of a man with multiple male and female family members affected by neuropathy who carries a pathologic mutation in GJB1. He has experienced three transient episodes with variable neurological deficits over the course of 7 years with corresponding changes on magnetic resonance imaging (MRI). This case illustrates CMT1X as a rare cause of transient neurological deficit and demonstrates the evolution of associated reversible abnormalities on MRI over time. To the best of our knowledge, this report provides the longest period of serial imaging in a single patient with this condition in the English language literature.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalCase Reports in Neurology
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2015

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Charcot-Marie-Tooth Disease
Connexins
Tooth
Stroke
Hereditary Sensory and Motor Neuropathy
Magnetic Resonance Imaging
Leukoencephalopathies
Mutation
Schwann Cells
Oligodendroglia
Language
Genes
Inherited Peripheral Neuropathy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Wu, Ning ; Said, Sarita ; Sabat, Shyamsunder ; Wicklund, Matthew ; Stahl, Mark C. / Recurrent Episodes of Stroke-Like Symptoms in a Patient with Charcot-Marie-Tooth Neuropathy X Type 1. In: Case Reports in Neurology. 2015 ; Vol. 7, No. 3. pp. 247-252.
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Recurrent Episodes of Stroke-Like Symptoms in a Patient with Charcot-Marie-Tooth Neuropathy X Type 1. / Wu, Ning; Said, Sarita; Sabat, Shyamsunder; Wicklund, Matthew; Stahl, Mark C.

In: Case Reports in Neurology, Vol. 7, No. 3, 01.01.2015, p. 247-252.

Research output: Contribution to journalArticle

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