Red Blood Cell Osmotic Fragility After Aortic Valve Replacement

Elaine Eyster, John Rothchild, Olga Mychajliw

    Research output: Contribution to journalArticle

    Abstract

    Red blood cell osmotic fragility and autohemolysis studies were performed on 35 patients with aortic ball-valve prostheses. Osmotic fragility on fresh heparinized blood was normal. After 24 hours' incubation, it was increased in 17 patients. The most common abnormality was a “tail” of cells with increased fragility indicative of a heterogeneous population of cells. Sixteen patients with increased fragility had cloth-covered Starr-Edwards prostheses; the majority had intravascular hemolysis. Nine patients with normal fragility had Cutter or Magovern prostheses; the majority had minimal hemolysis. Autohemolysis after 48 hours' incubation with glucose was normal in all patients. Increased incubated osmotic fragility frequently reflects damage to red blood cells by prosthetic heart valves, and increased osmotic fragility is often associated with increased rates of hemolysis in vivo. The damage is greater with cloth-covered Starr-Edwards than with Magovern or Cutter prostheses.

    Original languageEnglish (US)
    Pages (from-to)327-330
    Number of pages4
    JournalArchives of Internal Medicine
    Volume130
    Issue number3
    DOIs
    StatePublished - Sep 1972

    Fingerprint

    Osmotic Fragility
    Aortic Valve
    Erythrocytes
    Prostheses and Implants
    Hemolysis
    Heart Valves
    Glucose
    Population

    All Science Journal Classification (ASJC) codes

    • Internal Medicine

    Cite this

    Eyster, Elaine ; Rothchild, John ; Mychajliw, Olga. / Red Blood Cell Osmotic Fragility After Aortic Valve Replacement. In: Archives of Internal Medicine. 1972 ; Vol. 130, No. 3. pp. 327-330.
    @article{16879f2f6d714d5aaec46d52a6b1b01e,
    title = "Red Blood Cell Osmotic Fragility After Aortic Valve Replacement",
    abstract = "Red blood cell osmotic fragility and autohemolysis studies were performed on 35 patients with aortic ball-valve prostheses. Osmotic fragility on fresh heparinized blood was normal. After 24 hours' incubation, it was increased in 17 patients. The most common abnormality was a “tail” of cells with increased fragility indicative of a heterogeneous population of cells. Sixteen patients with increased fragility had cloth-covered Starr-Edwards prostheses; the majority had intravascular hemolysis. Nine patients with normal fragility had Cutter or Magovern prostheses; the majority had minimal hemolysis. Autohemolysis after 48 hours' incubation with glucose was normal in all patients. Increased incubated osmotic fragility frequently reflects damage to red blood cells by prosthetic heart valves, and increased osmotic fragility is often associated with increased rates of hemolysis in vivo. The damage is greater with cloth-covered Starr-Edwards than with Magovern or Cutter prostheses.",
    author = "Elaine Eyster and John Rothchild and Olga Mychajliw",
    year = "1972",
    month = "9",
    doi = "10.1001/archinte.1972.03650030015004",
    language = "English (US)",
    volume = "130",
    pages = "327--330",
    journal = "JAMA Internal Medicine",
    issn = "2168-6106",
    publisher = "American Medical Association",
    number = "3",

    }

    Red Blood Cell Osmotic Fragility After Aortic Valve Replacement. / Eyster, Elaine; Rothchild, John; Mychajliw, Olga.

    In: Archives of Internal Medicine, Vol. 130, No. 3, 09.1972, p. 327-330.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Red Blood Cell Osmotic Fragility After Aortic Valve Replacement

    AU - Eyster, Elaine

    AU - Rothchild, John

    AU - Mychajliw, Olga

    PY - 1972/9

    Y1 - 1972/9

    N2 - Red blood cell osmotic fragility and autohemolysis studies were performed on 35 patients with aortic ball-valve prostheses. Osmotic fragility on fresh heparinized blood was normal. After 24 hours' incubation, it was increased in 17 patients. The most common abnormality was a “tail” of cells with increased fragility indicative of a heterogeneous population of cells. Sixteen patients with increased fragility had cloth-covered Starr-Edwards prostheses; the majority had intravascular hemolysis. Nine patients with normal fragility had Cutter or Magovern prostheses; the majority had minimal hemolysis. Autohemolysis after 48 hours' incubation with glucose was normal in all patients. Increased incubated osmotic fragility frequently reflects damage to red blood cells by prosthetic heart valves, and increased osmotic fragility is often associated with increased rates of hemolysis in vivo. The damage is greater with cloth-covered Starr-Edwards than with Magovern or Cutter prostheses.

    AB - Red blood cell osmotic fragility and autohemolysis studies were performed on 35 patients with aortic ball-valve prostheses. Osmotic fragility on fresh heparinized blood was normal. After 24 hours' incubation, it was increased in 17 patients. The most common abnormality was a “tail” of cells with increased fragility indicative of a heterogeneous population of cells. Sixteen patients with increased fragility had cloth-covered Starr-Edwards prostheses; the majority had intravascular hemolysis. Nine patients with normal fragility had Cutter or Magovern prostheses; the majority had minimal hemolysis. Autohemolysis after 48 hours' incubation with glucose was normal in all patients. Increased incubated osmotic fragility frequently reflects damage to red blood cells by prosthetic heart valves, and increased osmotic fragility is often associated with increased rates of hemolysis in vivo. The damage is greater with cloth-covered Starr-Edwards than with Magovern or Cutter prostheses.

    UR - http://www.scopus.com/inward/record.url?scp=0015401128&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0015401128&partnerID=8YFLogxK

    U2 - 10.1001/archinte.1972.03650030015004

    DO - 10.1001/archinte.1972.03650030015004

    M3 - Article

    C2 - 5055689

    AN - SCOPUS:0015401128

    VL - 130

    SP - 327

    EP - 330

    JO - JAMA Internal Medicine

    JF - JAMA Internal Medicine

    SN - 2168-6106

    IS - 3

    ER -