Red hair, MC1R variants, and risk for Parkinson's disease - a meta-analysis

Xiqun Chen, Danielle Feng, Michael A. Schwarzschild, Xiang Gao

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.

Original languageEnglish (US)
JournalAnnals of Clinical and Translational Neurology
Volume4
Issue number3
DOIs
StatePublished - Mar 1 2017

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Parkinson Disease
Meta-Analysis
Hair Diseases
Odds Ratio
Confidence Intervals
Pigmentation
Publications
Melanoma
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

Cite this

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title = "Red hair, MC1R variants, and risk for Parkinson's disease - a meta-analysis",
abstract = "Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95{\%} confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95{\%} confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.",
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Red hair, MC1R variants, and risk for Parkinson's disease - a meta-analysis. / Chen, Xiqun; Feng, Danielle; Schwarzschild, Michael A.; Gao, Xiang.

In: Annals of Clinical and Translational Neurology, Vol. 4, No. 3, 01.03.2017.

Research output: Contribution to journalArticle

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