TY - JOUR
T1 - Red hair, MC1R variants, and risk for Parkinson's disease – a meta-analysis
AU - Chen, Xiqun
AU - Feng, Danielle
AU - Schwarzschild, Michael A.
AU - Gao, Xiang
N1 - Funding Information:
The authors are supported by the Michael J. Fox Foundation (9908 to X. C.), National Institute of Health (1R21NS090246-01A1 to X. C., 5R21NS087235-02 to X. G.), and National Natural Science Foundation of China (81471293 to X.C.).
Publisher Copyright:
© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
AB - Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
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U2 - 10.1002/acn3.381
DO - 10.1002/acn3.381
M3 - Article
AN - SCOPUS:85112512300
SN - 2328-9503
VL - 4
SP - 212
EP - 216
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 3
ER -