Redox cycling and lipid peroxidation: The central role of iron chelates

John R. Bucher, Ming Tien, Lee A. Morehouse, Steven D. Aust

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Redox Cycling and Lipid Peroxidation: The Central Role of Iron Chelates. Bucher, J.R., Tien, M., Morehouse, L.A. and Aust, S.D. (1983). Fundam. Appl. Toxicol. 3: 222-226. Toxicities associated with redox cycling, including lipid peroxidation, are often attributed to the hydroxyl radical through a superoxide-driven, iron-catalyzed Haber-Weiss reaction. However, other cellular reducing agents more prevalent than superoxide, I.e., glutathione, ascorbate, cysteine and certain enzymes, can also reduce chelated iron and thereby initiate lipid peroxidation which is not inhibited by superoxide dismutase. The autoxidation of ferrous chelates yields partially reduced oxygen intermediates similar to those produced during the iron-catalyzed Haber-Weiss reaction. The mechanism of their formation, and the nature of the strong oxidant responsible for the initiation of lipid peroxidation are poorly understood, but are apparently influenced by the chelation of the iron. These conclusions stem from experiments which demonstrated variable amounts of inhibition of lipid peroxidation, dependent on the autoxidation of various ferrous chelates, by added superoxide dismutase or catalase. In addition, certain ferrous chelates are unable to initiate peroxidation of lipids in a liposomal configuration, yet capable of initiating peroxidation of lipids which were dispersed with a detergent. The results of these studies point out the need to isolate and identify the predominant physiological iron chelates for assessment of their ability to participate in redox related toxicities within the cell.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalToxicological Sciences
Volume3
Issue number4
DOIs
StatePublished - Jul 1 1983

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Iron Chelating Agents
Lipid Peroxidation
Oxidation-Reduction
Lipids
Iron
Superoxides
Superoxide Dismutase
Toxicity
Reducing Agents
Chelation
Oxidants
Detergents
Hydroxyl Radical
Catalase
Glutathione
Cysteine
Oxygen
Enzymes

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Bucher, John R. ; Tien, Ming ; Morehouse, Lee A. ; Aust, Steven D. / Redox cycling and lipid peroxidation : The central role of iron chelates. In: Toxicological Sciences. 1983 ; Vol. 3, No. 4. pp. 222-226.
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Redox cycling and lipid peroxidation : The central role of iron chelates. / Bucher, John R.; Tien, Ming; Morehouse, Lee A.; Aust, Steven D.

In: Toxicological Sciences, Vol. 3, No. 4, 01.07.1983, p. 222-226.

Research output: Contribution to journalArticle

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