Reduced high-density lipoprotein level is linked to worse ankle brachial index and peak oxygen uptake in postmenopausal women with peripheral arterial disease

Karin Mauer, J. Emilio Exaire, Julie A. Stoner, Leslie D. Guthery, Polly S. Montgomery, Andrew Gardner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Women with peripheral arterial disease (PAD) have more limited physical function than men but the mechanisms involved are not clear. We determined whether alterations in lipid components, such as decreased high-density lipoprotein cholesterol (HDL-C), are associated with worsening intermittent claudication (IC) in postmenopausal women with PAD. Our cross-sectional cohort study included 69 postmenopausal women with IC (Fontaine stage II). A treadmill test was used to measure initial claudication distance (ICD), absolute claudication distance (ACD), peak oxygen uptake, and ankle systolic blood pressure. High-density lipoprotein cholesterol correlated with ankle brachial index ([ABI]; R =.29, P =.019). No other lipid profile components were associated with exercise performance and hemodynamic measures. Among women with HDL-C <50 mg/dL (n = 43), the median peak oxygen uptake level was significantly lower (P =.021) relative to women with normal HDL-C >50 mg/dL (n = 26). Lower HDL-C levels are associated with worse ABI and decreased peak oxygen uptake in postmenopausal women with PAD.

Original languageEnglish (US)
Pages (from-to)698-704
Number of pages7
JournalAngiology
Volume61
Issue number7
DOIs
StatePublished - Jan 1 2010

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Ankle Brachial Index
Peripheral Arterial Disease
HDL Lipoproteins
HDL Cholesterol
Oxygen
Intermittent Claudication
Blood Pressure
Lipids
Exercise Test
Ankle
Cohort Studies
Cross-Sectional Studies
Hemodynamics
Exercise

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Mauer, Karin ; Exaire, J. Emilio ; Stoner, Julie A. ; Guthery, Leslie D. ; Montgomery, Polly S. ; Gardner, Andrew. / Reduced high-density lipoprotein level is linked to worse ankle brachial index and peak oxygen uptake in postmenopausal women with peripheral arterial disease. In: Angiology. 2010 ; Vol. 61, No. 7. pp. 698-704.
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Reduced high-density lipoprotein level is linked to worse ankle brachial index and peak oxygen uptake in postmenopausal women with peripheral arterial disease. / Mauer, Karin; Exaire, J. Emilio; Stoner, Julie A.; Guthery, Leslie D.; Montgomery, Polly S.; Gardner, Andrew.

In: Angiology, Vol. 61, No. 7, 01.01.2010, p. 698-704.

Research output: Contribution to journalArticle

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