Reduced Thirst after Water Deprivation in Healthy Elderly Men

Paddy A. Phillips, Barbara Jean Rolls, John G.G. Ledingham, Mary L. Forsling, James J. Morton, Morgan J. Crowe, Leopold Wollner

Research output: Contribution to journalArticle

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Abstract

To determine whether responses to dehydration are altered with age, we investigated the thirst, fluid and electrolyte responses, and hormonal responses to 24 hours of water deprivation in seven healthy active elderly men (67 to 75 years old) and seven healthy young men (20 to 31 years old) who were matched for weight loss during water deprivation. After water deprivation, the older men had greater increases in plasma osmolality, sodium concentration, and vasopressin levels. However, their urinary osmolality was lower and they were less thirsty and drank less after water deprivation, so that their plasma and urine were not diluted to predeprivation levels. Regression analysis indicated increased sensitivity of vasopressin osmoreceptors in the older group, although this difference was not statistically significant. We conclude that after 24 hours of water deprivation, there is a deficit in thirst and water intake in healthy elderly men, as compared with younger men, although vasopressin osmoreceptor responsiveness is maintained or even increased. Our findings also suggest that the well-known deficit in urinary concentrating ability that occurs with age reflects renal causes and not a lack of circulating vasopressin. (N Engl J Med 1984; 311:753–9.).

Original languageEnglish (US)
Pages (from-to)753-759
Number of pages7
JournalNew England Journal of Medicine
Volume311
Issue number12
DOIs
StatePublished - Sep 20 1984

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Water Deprivation
Thirst
Vasopressins
Osmolar Concentration
Aptitude
Dehydration
Electrolytes
Drinking
Weight Loss
Sodium
Regression Analysis
Urine
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Phillips, P. A., Rolls, B. J., Ledingham, J. G. G., Forsling, M. L., Morton, J. J., Crowe, M. J., & Wollner, L. (1984). Reduced Thirst after Water Deprivation in Healthy Elderly Men. New England Journal of Medicine, 311(12), 753-759. https://doi.org/10.1056/NEJM198409203111202
Phillips, Paddy A. ; Rolls, Barbara Jean ; Ledingham, John G.G. ; Forsling, Mary L. ; Morton, James J. ; Crowe, Morgan J. ; Wollner, Leopold. / Reduced Thirst after Water Deprivation in Healthy Elderly Men. In: New England Journal of Medicine. 1984 ; Vol. 311, No. 12. pp. 753-759.
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Phillips, PA, Rolls, BJ, Ledingham, JGG, Forsling, ML, Morton, JJ, Crowe, MJ & Wollner, L 1984, 'Reduced Thirst after Water Deprivation in Healthy Elderly Men', New England Journal of Medicine, vol. 311, no. 12, pp. 753-759. https://doi.org/10.1056/NEJM198409203111202

Reduced Thirst after Water Deprivation in Healthy Elderly Men. / Phillips, Paddy A.; Rolls, Barbara Jean; Ledingham, John G.G.; Forsling, Mary L.; Morton, James J.; Crowe, Morgan J.; Wollner, Leopold.

In: New England Journal of Medicine, Vol. 311, No. 12, 20.09.1984, p. 753-759.

Research output: Contribution to journalArticle

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Phillips PA, Rolls BJ, Ledingham JGG, Forsling ML, Morton JJ, Crowe MJ et al. Reduced Thirst after Water Deprivation in Healthy Elderly Men. New England Journal of Medicine. 1984 Sep 20;311(12):753-759. https://doi.org/10.1056/NEJM198409203111202