Reduced vaccination and the risk of measles and other childhood infections post-Ebola

Saki Takahashi, C. Jessica E. Metcalf, Matthew Joseph Ferrari, William J. Moss, Shaun A. Truelove, Andrew J. Tatem, Bryan T. Grenfell, Justin Lessler

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The Ebola epidemic in West Africa has caused substantial morbidity and mortality. The outbreak has also disrupted health care services, including childhood vaccinations, creating a second public health crisis. We project that after 6 to 18 months of disruptions, a large connected cluster of children unvaccinated for measles will accumulate across Guinea, Liberia, and Sierra Leone. This pool of susceptibility increases the expected size of a regional measles outbreak from 127,000 to 227,000 cases after 18 months, resulting in 2000 to 16,000 additional deaths (comparable to the numbers of Ebola deaths reported thus far). There is a clear path to avoiding outbreaks of childhood vaccine-preventable diseases once the threat of Ebola begins to recede: an aggressive regional vaccination campaign aimed at age groups left unprotected because of health care disruptions.

Original languageEnglish (US)
Pages (from-to)1240-1242
Number of pages3
JournalScience
Volume347
Issue number6227
DOIs
StatePublished - Mar 13 2015

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Ebola Hemorrhagic Fever
Measles
Disease Outbreaks
Vaccination
Liberia
Sierra Leone
Guinea
Delivery of Health Care
Immunization Programs
Western Africa
Health Services
Vaccines
Public Health
Age Groups
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • General

Cite this

Takahashi, S., Metcalf, C. J. E., Ferrari, M. J., Moss, W. J., Truelove, S. A., Tatem, A. J., ... Lessler, J. (2015). Reduced vaccination and the risk of measles and other childhood infections post-Ebola. Science, 347(6227), 1240-1242. https://doi.org/10.1126/science.aaa3438
Takahashi, Saki ; Metcalf, C. Jessica E. ; Ferrari, Matthew Joseph ; Moss, William J. ; Truelove, Shaun A. ; Tatem, Andrew J. ; Grenfell, Bryan T. ; Lessler, Justin. / Reduced vaccination and the risk of measles and other childhood infections post-Ebola. In: Science. 2015 ; Vol. 347, No. 6227. pp. 1240-1242.
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Takahashi, S, Metcalf, CJE, Ferrari, MJ, Moss, WJ, Truelove, SA, Tatem, AJ, Grenfell, BT & Lessler, J 2015, 'Reduced vaccination and the risk of measles and other childhood infections post-Ebola', Science, vol. 347, no. 6227, pp. 1240-1242. https://doi.org/10.1126/science.aaa3438

Reduced vaccination and the risk of measles and other childhood infections post-Ebola. / Takahashi, Saki; Metcalf, C. Jessica E.; Ferrari, Matthew Joseph; Moss, William J.; Truelove, Shaun A.; Tatem, Andrew J.; Grenfell, Bryan T.; Lessler, Justin.

In: Science, Vol. 347, No. 6227, 13.03.2015, p. 1240-1242.

Research output: Contribution to journalArticle

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Takahashi S, Metcalf CJE, Ferrari MJ, Moss WJ, Truelove SA, Tatem AJ et al. Reduced vaccination and the risk of measles and other childhood infections post-Ebola. Science. 2015 Mar 13;347(6227):1240-1242. https://doi.org/10.1126/science.aaa3438