Reducing Dimensionality in the Search for Gene-Gene Interactions

Marylyn D. Ritchie

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gene-gene interactions are a critical component of the genetic architecture of complex, human traits. Unfortunately, the detection and characterization of interactions is a challenge. This is due to a number of factors including the combinatorial explosion of possible interactions in large-scale genomic data, limited power in small sample sizes, and potential difficulty interpreting or validating the resulting interaction models. A number of data mining methods have been developed to deal with one or more of these challenges. In this chapter, we discuss the importance of looking for gene-gene interactions as well as some of the challenges facing this type of analysis. Additionally, we review the alternative analytic approaches being considered to improve our ability to detect and model gene-gene interactions. Finally, we conclude with the future directions of interaction analysis.

Original languageEnglish (US)
Title of host publicationBetween the Lines of Genetic Code
Subtitle of host publicationGenetic Interactions in Understanding Disease and Complex Phenotypes
PublisherElsevier Inc.
Pages25-37
Number of pages13
ISBN (Print)9780123970176
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Ritchie, M. D. (2014). Reducing Dimensionality in the Search for Gene-Gene Interactions. In Between the Lines of Genetic Code: Genetic Interactions in Understanding Disease and Complex Phenotypes (pp. 25-37). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397017-6.00002-7