Reducing parenteral energy and protein intake improves metabolic homeostasis after bone marrow transplantation

A. Taveroff, A. H. McArdle, W. B. Rybka

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The purpose of this prospective study was to compare the metabolic effects of reducing parenteral energy and protein intake in bone-marrow-transplant (BMT) patients from 150% (hi-TPN group) to 100% (lo-TPN group) basal energy expenditure. Cytotoxic therapy was given on days 1-5, BMT on day 6, and TPN beginning on days 6 or 7. The lo-TPN group exhibited higher serum albumin (38 ± 0.4 vs 32 ± 0.4 g/L, P < 0.01) but similar nitrogen balance (-83 ± 8 vs -86 ± 8 mg · kg-1 · d-1, P > 0.05). Serum Na+ remained > 134 ± 1 mmol/L in the lo-TPN group but fell to 127 ± 1 mmol/L in the hi-TPN group (P < 0.001) despite similar Na+ intakes and balances. Serum K+ remained < 4.4 ± 0.2 mmol/L in the lo-TPN group but rose to 5.1 ± 0.1 mmol/L in the hi-TPN group (P < 0.01) despite similar K+ intakes and balances. Delivering TPN at lower-than-normal rates after BMT appears to minimize Na+ and K+ disturbances and improve serum albumin concentrations without having any adverse effect on nitrogen balance.

Original languageEnglish (US)
Pages (from-to)1087-1092
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume54
Issue number6
DOIs
StatePublished - Jan 1 1991

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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