Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells

Qingsong Qin, Matthew Lauver, Saumya Maru, Eugene Lin, Aron E. Lukacher

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Mouse polyomavirus (MuPyV) causes a smoldering persistent infection in immunocompetent mice. To lower MuPyV infection in acutely and persistently infected mice, and study the impact of a temporal reduction in viral loads on the memory CD8 T cell response, we created a recombinant MuPyV in which a loxP sequence was inserted into the A2 strain genome upstream of the early promoter and another loxP sequence was inserted in cis into the intron shared by all three T antigens. Using mice transgenic for tamoxifen-inducible Cre recombinase, we demonstrated that reduction in MuPyV load during persistent infection was associated with differentiation of virus-specific CD8 T cells having a superior recall response. Evidence presented here supports the concept that reduction in viral load during persistent infection can promote differentiation of protective virus-specific memory CD8 T cells in patients at risk for diseases caused by human polyomaviruses.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalVirology
Volume502
DOIs
StatePublished - Feb 1 2017

All Science Journal Classification (ASJC) codes

  • Virology

Fingerprint Dive into the research topics of 'Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells'. Together they form a unique fingerprint.

Cite this